Department of Food Biotechnology, Faculty of Food Technology, University of Agriculture, ul. Balicka 122, 30-149 Krakow, Poland.
Pharmaceuticals (Basel). 2014 Sep 4;7(9):913-42. doi: 10.3390/ph7090913.
Mitochondria are crucially important for maintaining not only the energy homeostasis, but the proper cellular functions in a general sense. Impairment of mitochondrial functions is observed in a broad variety of pathological states such as neoplastic transformations and cancer, neurodegenerative diseases, metabolic disorders and chronic inflammation. Currently, in parallel to the classical drug design approaches, there is an increasing interest in the screening for natural bioactive substances, mainly phytochemicals, in order to develop new therapeutic solutions for the mentioned pathologies. Dietary phytochemicals such as resveratrol, curcumin and sulforaphane are very well tolerated and can effectively complement classical pharmacological therapeutic regimens. In this paper we disscuss the effect of the chosen phytochemicals (e.g., resveratrol, curcumin, sulforaphane) on various aspects of mitochondrial biology, namely mitochondrial biogenesis, membrane potential and reactive oxygen species production, signaling to and from the nucleus and unfolded protein response.
线粒体对于维持能量平衡以及一般意义上的细胞正常功能至关重要。在多种病理状态下，如肿瘤转化和癌症、神经退行性疾病、代谢紊乱和慢性炎症，都观察到线粒体功能的损伤。目前，除了经典的药物设计方法之外，人们越来越关注筛选天然生物活性物质，主要是植物化学物质，以开发针对上述疾病的新治疗方法。膳食植物化学物质，如白藜芦醇、姜黄素和萝卜硫素，具有很好的耐受性，并且可以有效地补充经典的药理学治疗方案。在本文中，我们讨论了所选植物化学物质（如白藜芦醇、姜黄素、萝卜硫素）对线粒体生物学各个方面的影响，即线粒体生物发生、膜电位和活性氧物质的产生、细胞核内外的信号转导以及未折叠蛋白反应。
