漂白术后氟化物处理对牙齿脱矿的影响：一项体外研究。
Does post-bleaching fluoridation affect the further demineralization of bleached enamel? An in vitro study.
机构信息
Department of Restorative Dentistry, Faculty of Dentistry, Ege University, Bornova 35100, Izmir, Turkey.
出版信息
BMC Oral Health. 2014 Sep 6;14:113. doi: 10.1186/1472-6831-14-113.
BACKGROUND
Topical fluoride agents have been shown to be the most effective method in treating demineralized enamel after in-office bleaching treatments. Thus, this study aimed to examine the effects of two different post-bleaching fluoridation agents: 1.5% titanium tetrafluoride (TiF(4)) (9200 ppm) and 2.1% sodium fluoride (NaF) (9500 ppm), on the calcium loss of enamel after an acidic challenge.
METHODS
Ten maxillary premolars were sectioned into four pieces and then divided into the following four groups: Group 1: Control, kept in artificial saliva, no treatment; Group 2: 38% hydrogen peroxide (HP); Group 3: 38% HP followed by 1.5% TiF(4); Group 4: 38% HP followed by 2.1% NaF solution. The specimens were subjected to demineralization for 16 days, refreshing the solution every 4 days; that is, on the 4th, 8th, 12th, and 16th days. Calcium ion (Ca(2+)) concentration was determined by an atomic absorption spectrophotometer. Data were analyzed using Friedman and Wilcoxon tests (p = 0.05).
RESULTS
The loss of Ca(2+) in each of the test groups was compared with that of the control group, depicting that there was a statistically significant difference among the groups after 4, 8, 12, and 16 days and in total (p < 0.05). The calcium released from the fluoride-applied groups was lower when compared with the 38% HP and control group. At the end of the 16th day, the total amount of calcium released from the TiF(4-)treated samples (9.12 mg/mL) was less than from the NaF-treated samples (13.67 mg/mL) (p < 0.05).
CONCLUSIONS
Regarding the results of our in vitro study, the risk of further demineralization was significantly reduced with the use of TiF(4) and NaF after bleaching with 38% HP. TiF(4) was found to be more effective in preventing Ca2+ release owing to acid attack when compared with NaF. In the case of an intra-oral acidic exposure, the use of topical 1.5% TiF(4) and 2.1% NaF agents might be beneficial after bleaching with 38% HP.
背景
局部用氟化物已被证明是治疗诊室漂白治疗后脱矿釉质的最有效方法。因此，本研究旨在研究两种不同的漂白后氟化剂的效果：1.5%四氟化钛（TiF4）（9200ppm）和 2.1%氟化钠（NaF）（9500ppm）对酸蚀后牙釉质钙流失的影响。
方法
将 10 颗上颌前磨牙分为四部分，然后分为以下四组：第 1 组：对照组，置于人工唾液中，不做任何处理；第 2 组：38%过氧化氢（HP）；第 3 组：38%HP 后用 1.5%TiF4处理；第 4 组：38%HP 后用 2.1%NaF 溶液处理。标本经脱矿化处理 16 天，每 4 天更新溶液，即第 4、8、12 和 16 天。用原子吸收分光光度计测定钙离子（Ca2+）浓度。采用 Friedman 和 Wilcoxon 检验（p=0.05）对数据进行分析。
结果
比较各组试验组与对照组的 Ca2+丢失情况，表明 4、8、12 和 16 天及总时间点各组间差异有统计学意义（p<0.05）。与 38%HP 和对照组相比，应用氟化物的组释放的钙较低。第 16 天结束时，TiF4处理样本释放的总钙量（9.12mg/mL）少于 NaF 处理样本（13.67mg/mL）（p<0.05）。
结论
根据我们的体外研究结果，用 38%HP 漂白后，使用 TiF4和 NaF 可显著降低进一步脱矿的风险。与 NaF 相比，TiF4在酸蚀攻击时更能有效防止 Ca2+释放。在口腔内酸性暴露的情况下，用 38%HP 漂白后，局部使用 1.5%TiF4和 2.1%NaF 制剂可能是有益的。
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