Dembitsky Valery M
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, Ein Kerem Campus, P.O. Box 12065, Jerusalem 91120, Israel.
Eur J Med Chem. 2008 Feb;43(2):223-51. doi: 10.1016/j.ejmech.2007.04.019. Epub 2007 May 18.
Present review describes research on more than 280 natural anticancer agents isolated from terrestrial and marine sources and synthetic biologically active peroxides. Intensive searches for new classes of pharmacologically potent agents produced by terrestrial and marine organisms have resulted in the discovery of dozens of compounds possessing high cytotoxic, antibacterial, antimalarial, and other activities as an important source of leads for drug discovery.
本综述描述了对从陆地和海洋来源分离出的280多种天然抗癌剂以及合成生物活性过氧化物的研究。对陆地和海洋生物产生的新型药理活性药物的深入探索，已发现了数十种具有高细胞毒性、抗菌、抗疟和其他活性的化合物，这些化合物是药物研发重要的先导化合物来源。
