Sarkhail Parisa
Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 16th Azar Street, PO Box 14155-6451, Tehran 14176, Iran.
J Ethnopharmacol. 2014 Oct 28;156:235-70. doi: 10.1016/j.jep.2014.08.034. Epub 2014 Sep 3.
The genus Peucedanum (Apiaceae) comprising more than 120 species is widely distributed in Europe, Asia and Africa. The ethnopharmacologial history of this genus indicated that some extracts of aerial and underground parts of several Peucedanum species have been used in folk medicine for treatment of various conditions, such as cough, cramps, pain, rheumatism, asthma and angina. This review focuses on ethnopharmacological uses of Peucedanum species, as well as the phytochemical, pharmacological and toxicological studies on this genus. Through this review, I intend to highlight the known and potential effects of the Peucedanum species or their isolated compounds and show which traditional medicine uses have been supported by pharmacological investigations.
Information on the Peucedanum species was collected from scientific journals, books, thesis and reports via a library and electronic search (using Google Scholar, Pubmed, Scopus, Web of Science and ScienceDirect). This review covers the available literature from 1970 to the end of September 2013.
Although, there are about 120 species in this genus, so far many species have received no or little attention and most of pharmacological studies were performed on just about 20 species. Many phytochemical investigations on this genus confirmed that Peucedanum species are rich in essential oils and coumarins. The present review article shows that Peucedanum species have a wide spectrum of pharmacological activities and the most reported activities of Peucedanum plants come back to the presence of coumarins, flavonoids, phenolics and essential oils.
The present review confirms that some Peucedanum species have emerged as a good source of the traditional medicine for treatment of inflammation, microbial infections, cardiopulmonary diseases and provides new insights for further investigations on isolated compounds, especially on praeruptorins, to find novel therapeutics and aid drug discovery. However, for using Peucedanum species to prevent and treat various diseases, additional pharmacological studies to find the mechanism of action, safety and efficacy of them before starting clinical trials are required.
前胡属（伞形科）包含120多个物种，广泛分布于欧洲、亚洲和非洲。该属的民族药理学历史表明，几种前胡属植物地上和地下部分的一些提取物已被用于民间医学，治疗各种病症，如咳嗽、痉挛、疼痛、风湿、哮喘和心绞痛。本综述聚焦于前胡属植物的民族药理学用途，以及对该属植物的植物化学、药理学和毒理学研究。通过本综述，我旨在强调前胡属植物或其分离化合物的已知和潜在作用，并展示哪些传统医学用途得到了药理学研究的支持。
通过图书馆检索和电子检索（使用谷歌学术、PubMed、Scopus、科学网和ScienceDirect），从前科学期刊、书籍、论文和报告中收集有关前胡属植物的信息。本综述涵盖了从1970年至2013年9月底的现有文献。
尽管该属约有120个物种，但到目前为止，许多物种未得到或很少得到关注，大多数药理学研究仅针对约20个物种进行。对该属的许多植物化学研究证实，前胡属植物富含精油和香豆素。本综述文章表明，前胡属植物具有广泛的药理活性，前胡属植物最常报道的活性归因于香豆素、黄酮类化合物、酚类和精油的存在。
本综述证实，一些前胡属植物已成为治疗炎症、微生物感染、心肺疾病的传统药物的良好来源，并为进一步研究分离化合物，特别是前胡素，以寻找新疗法和辅助药物发现提供了新见解。然而，为了使用前胡属植物预防和治疗各种疾病，在开始临床试验之前，需要进行额外的药理学研究以确定其作用机制、安全性和有效性。
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