Northern Border University, College of Sciences, Department of Biological Sciences, Arar, Saudi Arabia; University of Carthage, National Institute of Applied Science and Technology, Department of Biology, Laboratory of Plant Biotechnology, B.P. 676, 1080, Tunis Cedex, Tunisia.
J Ethnopharmacol. 2022 Feb 10;284:114447. doi: 10.1016/j.jep.2021.114447. Epub 2021 Nov 2.
The genus Deverra DC. (Apiaceae) comprising only 13 taxa (9 species and 4 subspecies level) with disjunctive distribution in South Africa, in North Africa to Arabian Ecoregion. Thesis, books, Scientific journals, and reports were referred to collect information on the Deverra species. This present work reviewed the literature from 1900 to the end of January 2021. The aim of the review is to highlight traditional uses, phytochemistry and pharmacological properties of the species of the genus. The ethnopharmacologial uses of plant taxa belonging to this genus indicated that plant extracts, Essentail Oils (EOs) and infusion of aerial parts (APs) have been used in traditional popular medicine. The plants are used as a treatment of various purposes, such as asthma, rheumatism, fevers, hepatitis, diabetes and digestive difficulties. This present work focuses on ethnopharmacology of the Deverra species, the phytochemistry, pharmacology, toxicology among other studies on the genus. The present article summarizes on known and potential effects of the Deverra species as well as traditional medicine uses corroborated with pharmacological evidences. By the end of the review, Deverra species have a large application of bioactivities and the most described activities of Deverra plants are attributed to the presence of essential oils, coumarins, furocoumarins, flavonoids and phenolics. CONCLUSIONS: The review confirms that some Deverra taxa have been reported as a valuable source for flavoring and as a condiment as well as in the traditional medicine for the treatment of hypertension, to relief stomach pain and against intestinal parasites against spasms, pains, diabetes, hepatitis, digestive difficulties, urinary infections … etc. Nonetheless, for the valorisation of Deverra species in order to prevent and treat various diseases, further pharmacological investigations are strongly required to determine the mechanism of action, test the safety and the efficacity before starting clinical trials at big scale.
德弗拉属（伞形科）仅由 13 个分类群组成（9 个种和 4 个亚种水平），分布在南非、北非到阿拉伯生态区。本文参考了论文、书籍、科学期刊和报告，以收集有关德弗拉物种的信息。本研究综述了 1900 年至 2021 年 1 月底的文献。综述的目的是强调该属物种的传统用途、植物化学和药理学特性。属于该属的植物类群的民族植物学用途表明，植物提取物、精油（EOs）和地上部分的浸液（APs）已被用于传统民间医学。这些植物被用于治疗各种疾病，如哮喘、风湿、发热、肝炎、糖尿病和消化困难。本文重点介绍了德弗拉属植物的民族药理学、植物化学、药理学、毒理学以及该属的其他研究。本文总结了已知和潜在的德弗拉属植物的作用以及与药理学证据相吻合的传统医学用途。综述结束时，德弗拉属植物具有广泛的生物活性应用，描述最多的德弗拉植物活性归因于精油、香豆素、呋喃香豆素、类黄酮和酚类的存在。结论：综述证实，一些德弗拉分类群已被报道为调味剂和调味品的有价值来源，以及在传统医学中用于治疗高血压、缓解胃痛和对抗肠道寄生虫引起的痉挛、疼痛、糖尿病、肝炎、消化困难、尿路感染等疾病。然而，为了开发德弗拉属植物的价值，以预防和治疗各种疾病，需要进行进一步的药理学研究，以确定作用机制，测试安全性和有效性，然后才能在大范围内进行临床试验。
