Anderson A C, Hodges G R, Barnes W G
Arch Intern Med. 1976 Jul;136(7):785-7.
Determination of serum gentamicin levels (SGLs) is helpful in monitoring therapy in patients receiving this drug because there is a narrow therapeutic margin and serum levels may vary greatly between patients receiving similar doses. During a ten-month period, definite indications for obtaining SGL determinations were present for 189 of 212 serum samples (89.2%) submitted to the laboratory. However, 110 samples (51.9%) were improperly drawn and results of 85 samples (40.1%) were ignored. Only 26 of the 62 correctly drawn and not ignored samples (41.9%) were appropriately acted on. At most, 42 of the 212 samples (19.8%) were appropriately used in making patient-care decisions. Thus, in this study, an inordinatley large number of SGLs were incorrectly drawn, apparently ignored, or inappropriately used in making patient-care decisions.
测定血清庆大霉素水平（SGLs）有助于监测接受该药治疗的患者，因为其治疗窗较窄，且接受相似剂量药物的患者之间血清水平可能差异很大。在十个月的期间内，提交至实验室的212份血清样本中有189份（89.2%）存在进行SGL测定的明确指征。然而，110份样本（51.9%）采集不当，85份样本（40.1%）的结果被忽略。在62份采集正确且未被忽略的样本中，只有26份（41.9%）得到了适当处理。在212份样本中，最多只有42份（19.8%）被适当地用于指导患者护理决策。因此，在本研究中，大量的SGLs测定存在采集错误、明显被忽略或在指导患者护理决策时使用不当的情况。
