Department of Pediatrics 'F. Fede', Seconda Università degli Studi di Napoli, Napoli, Italy.
Int J Obes (Lond). 2010 Dec;34(12):1772-4. doi: 10.1038/ijo.2010.204. Epub 2010 Sep 28.
Iron deficiency has been linked to obesity. Hepcidin is the main regulator of iron homeostasis and is higher in obese children compared to controls. To gain insight into the link between obesity and hepcidin, we performed an intervention study in 15 obese children. These children were subjected to a 6-month weight loss program and underwent physical examination and iron status and absorption as well as hepcidin, interleukin-6 and leptin serum levels evaluation at baseline and after the weight loss program. After the program all children reduced their body mass index standard deviation score (BMI SDS) of at least 0.5. We observed a significant decrease in hepcidin (P=0.003) and leptin levels (P=0.005), and a significant increase in iron absorption (P=0.02). A direct correlation between the measure of hepcidin and leptin reduction was observed and this correlation appeared significant (r²=0.33, P=0.003) when adjusted for interleukin-6 and BMI SDS variations. In conclusion, we have shown that, in obese children, BMI reduction is associated with hepcidin reduction, potentially improving iron status and absorption. Implications of these findings could be considered in the management of obese children with poor iron status.
缺铁与肥胖有关。铁调素是铁稳态的主要调节剂，在肥胖儿童中高于对照。为了深入了解肥胖和铁调素之间的联系，我们对 15 名肥胖儿童进行了一项干预研究。这些儿童接受了为期 6 个月的减肥计划，并在基线和减肥计划后进行了体检以及铁状态和吸收以及铁调素、白细胞介素-6 和瘦素血清水平评估。在计划之后，所有儿童的体重指数标准差评分（BMI SDS）至少降低了 0.5。我们观察到铁调素（P=0.003）和瘦素水平（P=0.005）显著降低，铁吸收显著增加（P=0.02）。观察到铁调素和瘦素减少之间存在直接相关性，当调整白细胞介素-6 和 BMI SDS 变化时，这种相关性似乎很显著（r²=0.33，P=0.003）。总之，我们已经表明，在肥胖儿童中，BMI 降低与铁调素降低相关，可能改善铁状态和吸收。这些发现的影响可以在管理铁状态不佳的肥胖儿童时考虑。
