储存的红细胞输注：铁、炎症、免疫和感染。
Stored red blood cell transfusions: iron, inflammation, immunity, and infection.
机构信息
Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons-New York Presbyterian Hospital, New York, New York.
出版信息
Transfusion. 2014 Oct;54(10):2365-71. doi: 10.1111/trf.12848. Epub 2014 Sep 4.
Abstract
Emily Cooley was a highly regarded medical technologist and morphologist. The "Emily Cooley Lectureship and Award" was established to honor her, in particular, and medical technologists, in general. This article reviews some basic concepts about the "life of a red blood cell" (RBC) and uses these to discuss the actual and potential consequences that occur in patients after clearance of transfused refrigerator storage-damaged RBCs by extravascular hemolysis.
摘要
艾米丽·库利（Emily Cooley）是一位备受尊敬的医学技术专家和形态学家。设立“艾米丽·库利讲座和奖”是为了纪念她，特别是纪念医学技术专家。本文回顾了一些关于“红细胞（RBC）生命”的基本概念，并利用这些概念讨论了在体外溶血清除输注的冰箱储存损伤 RBC 后患者实际和潜在的后果。
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本文引用的文献
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Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model.在小鼠模型中，巨噬细胞可清除因冰箱储存而受损的红细胞，并随后在体内而非体外分泌细胞因子。
Transfusion. 2014 Dec;54(12):3186-97. doi: 10.1111/trf.12755. Epub 2014 Jul 20.
2
On the source of the non-transferrin-bound iron which accumulates in packed red blood cell units during storage.关于储存期间积聚在红细胞浓缩单位中的非转铁蛋白结合铁的来源。
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3
Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice.输注储存血液会损害小鼠对革兰氏阴性病原体的宿主防御能力。
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Tissue-resident macrophages.组织驻留巨噬细胞。
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