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储存的红细胞输注:铁、炎症、免疫和感染。

Stored red blood cell transfusions: iron, inflammation, immunity, and infection.

机构信息

Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons-New York Presbyterian Hospital, New York, New York.

出版信息

Transfusion. 2014 Oct;54(10):2365-71. doi: 10.1111/trf.12848. Epub 2014 Sep 4.

DOI:10.1111/trf.12848
PMID:25196845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4194176/
Abstract

Emily Cooley was a highly regarded medical technologist and morphologist. The "Emily Cooley Lectureship and Award" was established to honor her, in particular, and medical technologists, in general. This article reviews some basic concepts about the "life of a red blood cell" (RBC) and uses these to discuss the actual and potential consequences that occur in patients after clearance of transfused refrigerator storage-damaged RBCs by extravascular hemolysis.

摘要

艾米丽·库利(Emily Cooley)是一位备受尊敬的医学技术专家和形态学家。设立“艾米丽·库利讲座和奖”是为了纪念她,特别是纪念医学技术专家。本文回顾了一些关于“红细胞(RBC)生命”的基本概念,并利用这些概念讨论了在体外溶血清除输注的冰箱储存损伤 RBC 后患者实际和潜在的后果。

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1
Stored red blood cell transfusions: iron, inflammation, immunity, and infection.储存的红细胞输注:铁、炎症、免疫和感染。
Transfusion. 2014 Oct;54(10):2365-71. doi: 10.1111/trf.12848. Epub 2014 Sep 4.
2
Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.输注储存时间较长的异体红细胞可导致血管外溶血和循环中非转铁蛋白结合铁。
Blood. 2011 Dec 15;118(25):6675-82. doi: 10.1182/blood-2011-08-371849. Epub 2011 Oct 20.
3
Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.长期储存后的红细胞输注会产生有害影响,这些影响是由铁和炎症介导的。
Blood. 2010 May 27;115(21):4284-92. doi: 10.1182/blood-2009-10-245001. Epub 2010 Mar 18.
4
From cytokines to pragmatic designs: changing paradigms.从细胞因子到实用设计:不断变化的范式
Transfusion. 2017 Oct;57(10):2298-2306. doi: 10.1111/trf.14309. Epub 2017 Sep 4.
5
Transfusion-related biologic effects and free hemoglobin, heme, and iron.输血相关的生物学效应及游离血红蛋白、血红素和铁。
Transfusion. 2013 Apr;53(4):732-40. doi: 10.1111/j.1537-2995.2012.03837.x. Epub 2012 Aug 6.
6
Emily Cooley lecture 2012: Emily Cooley and techniques that have been applied to characterize DO and JR blood groups.艾米莉·库利 2012 年演讲:艾米莉·库利和已应用于特征化 DO 和 JR 血型的技术。
Transfusion. 2013 Sep;53(9):1876-83. doi: 10.1111/trf.12207. Epub 2013 Apr 15.
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Stored red blood cell transfusions: Iron, inflammation, immunity, and infection.储存红细胞输血:铁、炎症、免疫与感染
Transfus Clin Biol. 2012 Jun;19(3):84-9. doi: 10.1016/j.tracli.2012.04.001. Epub 2012 Jun 7.
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Effect of red blood cell storage time on markers of hemolysis and inflammation in transfused very low birth weight infants.红细胞储存时间对输注极低出生体重儿溶血和炎症标志物的影响。
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Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice.镰状细胞性状增加小鼠红细胞储存溶血和输血后清除率。
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Prolonged red cell storage before transfusion increases extravascular hemolysis.输血前红细胞长时间储存会增加血管外溶血。
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Transfused Red Blood Cell Characteristics and Kidney Transplant Outcomes Among Patients Receiving Early Posttransplant Transfusion.接受早期移植后输血的患者的输红细胞特征和肾移植结局。
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本文引用的文献

1
Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model.在小鼠模型中,巨噬细胞可清除因冰箱储存而受损的红细胞,并随后在体内而非体外分泌细胞因子。
Transfusion. 2014 Dec;54(12):3186-97. doi: 10.1111/trf.12755. Epub 2014 Jul 20.
2
On the source of the non-transferrin-bound iron which accumulates in packed red blood cell units during storage.关于储存期间积聚在红细胞浓缩单位中的非转铁蛋白结合铁的来源。
Blood Transfus. 2014 Oct;12(4):527-32. doi: 10.2450/2014.0271-13. Epub 2014 Jun 5.
3
Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice.
Blood Transfusion Predicts Prolonged Mechanical Ventilation in Acute Stanford Type A Aortic Dissection Undergoing Total Aortic Arch Replacement.
输血预示着接受全主动脉弓置换术的急性 Stanford A 型主动脉夹层患者机械通气时间延长。
Front Cardiovasc Med. 2022 Apr 15;9:832396. doi: 10.3389/fcvm.2022.832396. eCollection 2022.
4
Perioperative blood transfusions in hip and knee arthroplasty: a retrospective assessment of combined risk factors.髋关节和膝关节置换术围手术期输血:综合危险因素的回顾性评估。
Arch Orthop Trauma Surg. 2022 Aug;142(8):1817-1822. doi: 10.1007/s00402-021-03763-w. Epub 2021 Feb 19.
5
Mechanisms of red blood cell transfusion-related immunomodulation.红细胞输血相关免疫调节机制。
Transfusion. 2018 Mar;58(3):804-815. doi: 10.1111/trf.14488. Epub 2018 Jan 30.
6
Effect of "old" versus "fresh" transfused red blood cells on patients' outcome: probably more complex than appears.“陈旧”与“新鲜”输注红细胞对患者预后的影响:可能比表面看起来更复杂。
J Thorac Dis. 2017 Feb;9(2):E146-E148. doi: 10.21037/jtd.2017.02.03.
7
Duration of red blood cell storage and inflammatory marker generation.红细胞储存时间与炎症标志物生成
Blood Transfus. 2017 Mar;15(2):145-152. doi: 10.2450/2017.0343-16.
8
Perioperative Red Blood Cell Transfusion: What We Do Not Know.围手术期红细胞输血:我们所不知道的
Chin Med J (Engl). 2015 Sep 5;128(17):2383-6. doi: 10.4103/0366-6999.163384.
9
Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model.输注保存时间较长的老龄红细胞可改善犬类致死性出血和再灌注模型的临床病程及预后。
Transfusion. 2015 Nov;55(11):2552-63. doi: 10.1111/trf.13213. Epub 2015 Jul 15.
10
Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome.红细胞(RBC)单位在添加剂溶液-3中的常规储存:对红细胞代谢组的全面研究
Transfusion. 2015 Jun;55(6):1155-68. doi: 10.1111/trf.12975. Epub 2014 Dec 30.
输注储存血液会损害小鼠对革兰氏阴性病原体的宿主防御能力。
Transfusion. 2014 Nov;54(11):2842-51. doi: 10.1111/trf.12712. Epub 2014 May 19.
4
Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro.红细胞来源的外泌体与单核细胞结合,诱导促炎细胞因子产生,从而增强体外 T 细胞反应。
Blood. 2014 Jan 30;123(5):687-96. doi: 10.1182/blood-2013-10-530469. Epub 2013 Dec 12.
5
Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro.异前列腺素和异呋喃脂质介质在储存的红细胞中积累,并影响体外血小板功能。
Transfusion. 2014 Jun;54(6):1569-79. doi: 10.1111/trf.12485. Epub 2013 Nov 5.
6
Tissue-resident macrophages.组织驻留巨噬细胞。
Nat Immunol. 2013 Oct;14(10):986-95. doi: 10.1038/ni.2705. Epub 2013 Sep 18.
7
Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.单核细胞衍生的树突状细胞通过吞噬作用来精细调节过度的免疫反应。
Immunity. 2013 Sep 19;39(3):584-98. doi: 10.1016/j.immuni.2013.06.019. Epub 2013 Sep 12.
8
Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks.葡萄糖-6-磷酸脱氢酶缺乏症在输血医学中的未知风险
Vox Sang. 2013 Nov;105(4):271-82. doi: 10.1111/vox.12068. Epub 2013 Jul 2.
9
Transfusion of 28-day-old leucoreduced or non-leucoreduced stored red blood cells induces an inflammatory response in healthy dogs.输注 28 日龄去白细胞或未去白细胞的贮存红细胞可引起健康犬的炎症反应。
Vox Sang. 2013 Nov;105(4):319-27. doi: 10.1111/vox.12058. Epub 2013 Jun 13.
10
Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model.在小鼠模型中,红细胞的储存、代谢和类二十烷酸生成具有菌株特异性。
Transfusion. 2014 Jan;54(1):137-48. doi: 10.1111/trf.12264. Epub 2013 May 30.