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Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients.尿路上皮蛋白1A表达降低与胃腺癌患者的不良预后相关。
PLoS One. 2014 Apr 3;9(4):e93073. doi: 10.1371/journal.pone.0093073. eCollection 2014.
2
Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors.结直肠癌流行病学：发病率、死亡率、生存率及风险因素。
Clin Colon Rectal Surg. 2009 Nov;22(4):191-7. doi: 10.1055/s-0029-1242458.
3
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma.尿路上皮多瘤病毒 1A 基因在食管鳞癌中的抑癌作用研究
Cancer Res. 2010 Nov 1;70(21):8832-41. doi: 10.1158/0008-5472.CAN-10-0779. Epub 2010 Oct 26.
4
Epidemiology of colorectal cancer in Asia.亚洲结直肠癌的流行病学。
J Gastroenterol Hepatol. 2009 Dec;24(12):1810-6. doi: 10.1111/j.1440-1746.2009.06138.x.
5
Uroplakins in urothelial biology, function, and disease.尿路上皮生物学、功能及疾病中的尿血小板溶素
Kidney Int. 2009 Jun;75(11):1153-1165. doi: 10.1038/ki.2009.73. Epub 2009 Apr 1.
6
Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer.尿路上皮蛋白III表达缺失与侵袭性膀胱癌的临床病理特征相关。
Urology. 2008 Aug;72(2):444-9. doi: 10.1016/j.urology.2007.11.128. Epub 2008 Mar 3.
7
Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome.晚期尿路上皮癌中尿路上皮蛋白的持续表达：对尿路上皮肿瘤进展和临床结局的影响
Hum Pathol. 2007 Nov;38(11):1703-13. doi: 10.1016/j.humpath.2007.04.003. Epub 2007 Aug 17.
8
Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia.尿血小板溶素Ia和Ib独特的聚糖结构：FimH黏附素与尿血小板溶素Ia选择性结合的结构基础。
J Biol Chem. 2006 May 26;281(21):14644-53. doi: 10.1074/jbc.M600877200. Epub 2006 Mar 27.
9
Uroplakin Ib gene transcription in urothelial tumor cells is regulated by CpG methylation.尿路上皮肿瘤细胞中uroplakin Ib基因的转录受CpG甲基化调控。
Neoplasia. 2005 Dec;7(12):1091-103. doi: 10.1593/neo.05364.
10
Uroplakin II as a promising marker for molecular diagnosis of nodal metastases from bladder cancer: comparison with cytokeratin 20.尿路上皮蛋白II作为膀胱癌淋巴结转移分子诊断的一种有前景的标志物：与细胞角蛋白20的比较。
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尿路上皮蛋白Ia表达降低与结直肠癌进展及患者不良生存相关。

Decreased expression of uroplakin Ia is associated with colorectal cancer progression and poor survival of patients.

作者信息

He Yongzhong, Kong Fandong, Du Hanpeng, Wu Mingjian

机构信息

Department of General Surgery, The Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, GD 511400, China.

出版信息

Int J Clin Exp Pathol. 2014 Jul 15;7(8):5031-7. eCollection 2014.

PMID:25197375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4152065/
Abstract

AIM

The present study was to investigate the clinical significance of Uroplakins Ia (UPKIa) in the development of colorectal cancer.

METHODS

mRNA levels of UPKIa in paired colorectal cancer lesions and the adjacent noncancerous tissues were examined using real-time PCR. The expression and prognostic value of UPKIa were examined in 125 colorectal cancer patients after resection. Statistical analyses were applied to derive prognostic associations.

RESULTS

UPKIa mRNA level was down-regulated in colorectal cancer lesions compared with that in the paired adjacent noncancerous tissues. Reduced expression of UPKIa was significantly associated with clinical staging (P = 0.038), and tumor size (P = 0.035) of the disease. Moreover, low expression of UPKIa was significantly associated with poorer overall (OS) and recurrent free (RFS) survival (P = 0.017 and P = 0.007, respectively) of colorectal cancer patients. Multivariate analysis suggested that reduced expression of UPK1a was an independent prognostic marker of colorectal cancer (P = 0.047).

CONCLUSIONS

Low expression of UPKIa was a promising predictor for poor outcome of colorectal cancer patients. Further studies on the potential use of UPKIa as a therapeutic targetis are still needed.

摘要

目的

本研究旨在探讨尿路上皮蛋白Ia（UPKIa）在结直肠癌发生发展中的临床意义。

方法

采用实时荧光定量PCR检测125例结直肠癌患者手术切除标本中癌组织及癌旁正常组织中UPKIa的mRNA水平。分析UPKIa的表达情况及其对患者预后的影响，并进行统计学分析以得出预后相关性。

结果

与配对的癌旁正常组织相比，结直肠癌组织中UPKIa的mRNA水平下调。UPKIa表达降低与疾病的临床分期（P = 0.038）和肿瘤大小（P = 0.035）显著相关。此外，UPKIa低表达与结直肠癌患者较差的总生存期（OS）和无复发生存期（RFS）显著相关（分别为P = 0.017和P = 0.007）。多因素分析表明，UPK1a表达降低是结直肠癌的独立预后指标（P = 0.047）。

结论

UPKIa低表达是结直肠癌患者预后不良的一个有前景的预测指标。仍需进一步研究将UPKIa作为治疗靶点的潜在用途。