He Yongzhong, Kong Fandong, Du Hanpeng, Wu Mingjian
Department of General Surgery, The Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, GD 511400, China.
Int J Clin Exp Pathol. 2014 Jul 15;7(8):5031-7. eCollection 2014.
The present study was to investigate the clinical significance of Uroplakins Ia (UPKIa) in the development of colorectal cancer.
mRNA levels of UPKIa in paired colorectal cancer lesions and the adjacent noncancerous tissues were examined using real-time PCR. The expression and prognostic value of UPKIa were examined in 125 colorectal cancer patients after resection. Statistical analyses were applied to derive prognostic associations.
UPKIa mRNA level was down-regulated in colorectal cancer lesions compared with that in the paired adjacent noncancerous tissues. Reduced expression of UPKIa was significantly associated with clinical staging (P = 0.038), and tumor size (P = 0.035) of the disease. Moreover, low expression of UPKIa was significantly associated with poorer overall (OS) and recurrent free (RFS) survival (P = 0.017 and P = 0.007, respectively) of colorectal cancer patients. Multivariate analysis suggested that reduced expression of UPK1a was an independent prognostic marker of colorectal cancer (P = 0.047).
Low expression of UPKIa was a promising predictor for poor outcome of colorectal cancer patients. Further studies on the potential use of UPKIa as a therapeutic targetis are still needed.
本研究旨在探讨尿路上皮蛋白Ia（UPKIa）在结直肠癌发生发展中的临床意义。
采用实时荧光定量PCR检测125例结直肠癌患者手术切除标本中癌组织及癌旁正常组织中UPKIa的mRNA水平。分析UPKIa的表达情况及其对患者预后的影响，并进行统计学分析以得出预后相关性。
与配对的癌旁正常组织相比，结直肠癌组织中UPKIa的mRNA水平下调。UPKIa表达降低与疾病的临床分期（P = 0.038）和肿瘤大小（P = 0.035）显著相关。此外，UPKIa低表达与结直肠癌患者较差的总生存期（OS）和无复发生存期（RFS）显著相关（分别为P = 0.017和P = 0.007）。多因素分析表明，UPK1a表达降低是结直肠癌的独立预后指标（P = 0.047）。
UPKIa低表达是结直肠癌患者预后不良的一个有前景的预测指标。仍需进一步研究将UPKIa作为治疗靶点的潜在用途。
