Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University , Kakuma, Kanazawa 920-1192, Japan.
Org Lett. 2014 Sep 19;16(18):4854-7. doi: 10.1021/ol502347n. Epub 2014 Sep 8.
Highly efficient formation of 3-benzazepine derivatives has been achieved, based on the ring expansion reaction of C,N-cyclic-N'-acyl azomethine imines with sulfonium ylide generated in situ from the corresponding sulfonium salt. The reactions proceeded smoothly to afford the tricyclic 3-benzazepine derivatives in good to high yields. A wide range of C,N-cyclic N'-acyl azomethine imines were applicable to this reaction.
基于 C,N-环-N'-酰基亚甲胺亚胺与相应的锍盐原位生成的硫叶立德的环扩张反应，高效地合成了 3-苯并氮杂环衍生物。反应顺利进行，以良好到高产率得到三环 3-苯并氮杂环衍生物。广泛的 C,N-环-N'-酰基亚甲胺亚胺适用于该反应。
