Wiedmeyer Charles E, Crossland Janet P, Veres Monika, Dewey Michael J, Felder Michael R, Barlow Shayne C, Vrana Paul B, Szalai Gabor
Veterinary Medical Diagnostic Laboratory and Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.
Peromyscus Genetic Stock Center, Office of the Vice President for Research and University of South Carolina, Columbia, South Carolina, USA.
J Am Assoc Lab Anim Sci. 2014 Jul;53(4):336-43.
Deer mice (Peromyscus maniculatus) and congeneric species are used in a wide variety of research applications, particularly studies of developmental, physiologic, and behavioral characteristics associated with habitat adaptation and speciation. Because peromyscine mice readily adapt to colony conditions, animals with traits of interest in the field are moved easily into the laboratory where they can be studied under controlled conditions. The purpose of this study was to determine the serum chemistry and hematologic parameters of 4 frequently used species from the Peromyscus Genetic Stock Center species (P. californicus, P. leucopus, P. maniculatus, and P. polionotus) and to determine quantitative differences in these parameters among species and between sexes. Triglyceride values were substantially higher in female compared with male mice in all 4 species. Similar cross-species differences in MCH were present. Overall there was considerable interspecific variation for most blood parameters, with little evidence for covariation of any 2 or more parameters. Because crosses of P. maniculatus and P. polionotus produce fertile offspring, segregation analyses can be applied to determine the genetic basis of any traits that differ between them, such as their 3.8- and 2.1-fold interspecific differences in cholesterol and triglyceride levels, respectively. The current data provide a set of baseline values useful for subsequent comparative studies of species experiencing different circumstances, whether due to natural variation or anthropogenic environmental degradation. To enable such comparisons, the raw data are downloadable from a site maintained by the Stock Center (http://ww2.biol.sc.edu/∼peromyscus).
鹿鼠（白足鼠）及其同属物种被广泛应用于各种研究中，尤其是与栖息地适应和物种形成相关的发育、生理和行为特征的研究。由于鹿鼠科小鼠能很容易地适应圈养条件，因此在野外具有感兴趣特征的动物可以很容易地转移到实验室，在可控条件下进行研究。本研究的目的是确定来自白足鼠遗传种群中心的4种常用物种（加州白足鼠、白足鼠、鹿鼠和海滨白足鼠）的血清化学和血液学参数，并确定这些参数在物种间和性别间的定量差异。在所有4个物种中，雌性小鼠的甘油三酯值均显著高于雄性小鼠。平均红细胞血红蛋白含量（MCH）也存在类似的跨物种差异。总体而言，大多数血液参数存在相当大的种间差异，几乎没有证据表明任何两个或更多参数存在协变关系。由于鹿鼠和海滨白足鼠的杂交能产生可育后代，因此可以应用分离分析来确定它们之间存在差异的任何性状的遗传基础，比如它们在胆固醇和甘油三酯水平上分别存在3.8倍和2.1倍的种间差异。目前的数据提供了一组基线值，有助于后续对经历不同情况的物种进行比较研究，无论这些情况是由于自然变异还是人为环境退化造成的。为了便于进行此类比较，原始数据可从种群中心维护的网站（http://ww2.biol.sc.edu/∼peromyscus）下载。
