Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
Clin Transl Gastroenterol. 2019 Feb;10(2):e00005. doi: 10.14309/ctg.0000000000000005.
There is little evidence about gastrointestinal (GI) disorders in patients with schizophrenia. We examined association of schizophrenia with upper GI bleeding (UGIB) and nonbleeding ulcers and associated risk factors and mortality.
We used the data linked from population-based registries in Denmark. Among patients with incident schizophrenia in 1980-2011, we computed cumulative incidences and standardized incidence ratios of UGIB, bleeding ulcers, and nonbleeding ulcers compared with the general population; evaluated risk factors for the 3 GI endpoints, including somatic and psychiatric comorbidity; and examined subsequent all-cause mortality.
Among 39,998 patients with schizophrenia, the standardized incidence ratios were 2.92 (95% confidence interval (CI), 2.76-3.08) for UGIB, 2.36 (95% CI, 2.15-2.58) for bleeding ulcers, and 2.00 (95% CI, 1.87-2.15) for nonbleeding ulcers. Risk factors for UGIB and nonbleeding ulcers included age, somatic comorbidity, and medication use. UGIB and nonbleeding ulcers were associated with the subsequent increase in mortality.
Schizophrenia is associated with an increased risk of UGIB and nonbleeding ulcers, whose risk factors in patients with schizophrenia are similar to those in the general population.
精神分裂症患者的胃肠道（GI）疾病证据很少。我们研究了精神分裂症与上消化道出血（UGIB）和非出血性溃疡的关联，以及相关的危险因素和死亡率。
我们使用丹麦基于人群的登记处的数据进行了链接。在 1980 年至 2011 年期间患有精神分裂症的患者中，我们计算了 UGIB、出血性溃疡和非出血性溃疡与普通人群相比的累积发病率和标准化发病率比；评估了 3 个 GI 终点的危险因素，包括躯体和精神共病；并检查了随后的全因死亡率。
在 39998 名精神分裂症患者中，UGIB 的标准化发病率比为 2.92（95%置信区间[CI]，2.76-3.08），出血性溃疡为 2.36（95% CI，2.15-2.58），非出血性溃疡为 2.00（95% CI，1.87-2.15）。UGIB 和非出血性溃疡的危险因素包括年龄、躯体共病和药物使用。UGIB 和非出血性溃疡与随后的死亡率增加有关。
精神分裂症与 UGIB 和非出血性溃疡的风险增加有关，其危险因素与普通人群相似。
