Hillaire Marine L B, van Eijk Martin, Vogelzang-van Trierum Stella E, Nieuwkoop Nella J, van Riel Debby, Fouchier Ron A M, Kuiken Thijs, Osterhaus Albert D M E, Haagsman Henk P, Rimmelzwaan Guus F
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Virus Res. 2015 Jan 2;195:43-6. doi: 10.1016/j.virusres.2014.08.019. Epub 2014 Sep 6.
The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, there is an urgent need for the development of novel classes of antiviral drugs. Here we investigated the antiviral properties of recombinant porcine surfactant protein D (RpSP-D), an innate defense molecule with lectin properties, against influenza B viruses. We have previously shown that porcine SP-D has more potent neutralizing activity against influenza A viruses than human SP-D. Here we show that RpSP-D neutralizes influenza B viruses efficiently and inhibited the binding of these viruses to epithelial cells of the human trachea.
抗流感病毒的抗病毒药物储备有限。此外，还出现了对现有抗病毒药物如M2和NA抑制剂耐药的流感病毒。因此，迫切需要开发新型抗病毒药物。在此，我们研究了重组猪表面活性蛋白D（RpSP-D）（一种具有凝集素特性的天然防御分子）对乙型流感病毒的抗病毒特性。我们之前已经表明，猪SP-D对甲型流感病毒的中和活性比人SP-D更强。在此我们表明，RpSP-D能有效中和乙型流感病毒，并抑制这些病毒与人气管上皮细胞的结合。
