Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE, School of Environment, Hohai University, 210098 Nanjing, China.
Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE, School of Environment, Hohai University, 210098 Nanjing, China.
Chemosphere. 2015 Feb;120:383-90. doi: 10.1016/j.chemosphere.2014.07.098. Epub 2014 Sep 6.
The unsaturated fatty acid (linoleic acid) sustained-release microspheres were prepared with linoleic acid (LA) using alginate-chitosan microcapsule technology. These LA sustained-release microspheres had a high encapsulation efficiency (up to 62%) tested by high performance liquid chromatography with a photo diode array. The dry microspheres were characterized by a scanning electron microscope, X-ray diffraction measurement, dynamic thermogravimetric analysis and Fourier transform infrared spectral analysis. The results of characterization showed that the microspheres had good thermal stability (decomposition temperature of 236°C), stable and temperature independent release properties (release time of more than 40 d). Compared to direct dosing of LA, LA sustained-released microspheres could inhibit Microcystis aeruginosa growth to the non-growth state. The results of this study suggested that the LA sustained-release microspheres may be a potential candidate for algal inhibition.
采用海藻酸钠-壳聚糖微胶囊技术，以亚油酸（LA）为芯材制备不饱合脂肪酸（亚油酸）缓释微球。通过高效液相色谱法-光电二极管阵列法（HPLC-PDA）测试表明，该微球具有较高的包封率（最高可达 62%）。采用扫描电子显微镜（SEM）、X 射线衍射（XRD）、动态热重分析（TG-DTA）和傅里叶变换红外光谱（FTIR）对微球进行了表征。结果表明，微球具有良好的热稳定性（分解温度为 236°C）和稳定的、与温度无关的释放性能（释放时间超过 40 天）。与直接投加 LA 相比，LA 缓释微球可以抑制铜绿微囊藻的生长，使其处于非生长状态。研究结果表明，LA 缓释微球可能是一种潜在的抑藻候选药物。
