来自具有滑面内质网簇的卵母细胞的健康正常婴儿的分娩。
Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters.
作者信息
Hattori Hiromitsu, Nakamura Yusuke, Nakajo Yukiko, Araki Yasuhisa, Kyono Koichi
机构信息
Kyono ART Clinic, Mitsui-Seimei, Sendai Honcho Bl, 3F, 1-1-1 Honcho, Aoba-ku, Sendai, Miyagi, 980-0014, Japan.
出版信息
J Assist Reprod Genet. 2014 Nov;31(11):1461-7. doi: 10.1007/s10815-014-0323-z. Epub 2014 Sep 10.
Abstract
PURPOSE
To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes.
METHODS
Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) and those without (the SERC(-) group) in 2,158 patients (3,758 cycles) after ICSI.
RESULTS
Fertilization and implantation rate were significantly lower in SERC(+) MII oocytes than in SERC(-) MII oocytes. After the transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14 pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer (ET) and 12 from vitrified-warmed ET, with no malformations.
CONCLUSION(S): The presence of SERC in MII oocytes was associated with significantly lower fertilization rates and implantation rates than seen in SERC(-) MII oocytes within SERC (+) cycles. However, SERC had no impact on post-implantation development as well as neonatal outcome.
摘要
目的
研究人中期 II（MII）卵母细胞中滑面内质网簇（SERC）对衍生胚胎发育的影响。
方法
在基野辅助生殖诊所进行回顾性分析。比较2158例患者（3758个周期）卵胞浆内单精子注射（ICSI）后，有SERC的卵母细胞（SERC(+)组）和无SERC的卵母细胞（SERC(-)组）之间的胚胎发育、妊娠、活产和胎儿畸形情况。
结果
SERC(+) MII卵母细胞的受精率和着床率显著低于SERC(-) MII卵母细胞。在移植源自SERC(+)卵母细胞的新鲜和玻璃化胚胎后，14例妊娠分娩出14名健康婴儿，其中2例来自新鲜胚胎移植（ET），12例来自玻璃化复苏ET，无畸形。
结论
在SERC(+)周期内，MII卵母细胞中SERC的存在与受精率和着床率显著低于SERC(-) MII卵母细胞有关。然而，SERC对植入后发育以及新生儿结局没有影响。
相似文献
1
Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters.来自具有滑面内质网簇的卵母细胞的健康正常婴儿的分娩。
J Assist Reprod Genet. 2014 Nov;31(11):1461-7. doi: 10.1007/s10815-014-0323-z. Epub 2014 Sep 10.
2
Deliveries of normal healthy babies from embryos originating from oocytes showing the presence of smooth endoplasmic reticulum aggregates.正常健康婴儿的分娩来自于显示出光滑内质网聚集物的卵母细胞的胚胎。
Hum Reprod. 2013 Aug;28(8):2111-7. doi: 10.1093/humrep/det241. Epub 2013 May 21.
3
The relationship between pregnancy outcome and smooth endoplasmic reticulum clusters in MII human oocytes.MII期人类卵母细胞中妊娠结局与滑面内质网簇之间的关系。
Hum Reprod. 2004 Jul;19(7):1591-7. doi: 10.1093/humrep/deh258. Epub 2004 Jun 4.
4
Oocytes with smooth endoplasmic reticulum clusters originate blastocysts with impaired implantation potential.具有光滑内质网簇的卵母细胞起源于具有受损着床潜力的囊胚。
Fertil Steril. 2016 Dec;106(7):1718-1724. doi: 10.1016/j.fertnstert.2016.09.006. Epub 2016 Oct 12.
5
Clinical outcomes after IVF or ICSI using human blastocysts derived from oocytes containing aggregates of smooth endoplasmic reticulum.使用源自含有滑面内质网聚集体的卵母细胞的人类囊胚进行体外受精或卵胞浆内单精子注射后的临床结局。
Reprod Biomed Online. 2017 Apr;34(4):337-344. doi: 10.1016/j.rbmo.2017.01.007. Epub 2017 Jan 25.
6
The Relationship Between Smooth Endoplasmic Reticulum Clusters in Metaphase II Oocytes and Embryological and Birth Outcomes in Infertile Couples.中期II卵母细胞中滑面内质网簇与不育夫妇胚胎发育及出生结局的关系
Int J Gen Med. 2024 Jul 24;17:3269-3277. doi: 10.2147/IJGM.S469626. eCollection 2024.
7
Metaphase II (MII) human oocytes with smooth endoplasmic reticulum clusters do not affect blastocyst euploid rate.具有光滑内质网簇的中期 II（MII）人类卵母细胞不会影响囊胚的整倍体率。
Taiwan J Obstet Gynecol. 2022 Jul;61(4):585-589. doi: 10.1016/j.tjog.2021.03.044.
8
Smooth endoplasmic reticulum cluster presence does not affect embryo ploidy.内质网簇的存在并不会影响胚胎的倍性。
Arch Gynecol Obstet. 2023 May;307(5):1607-1612. doi: 10.1007/s00404-023-06969-y. Epub 2023 Feb 17.
9
Ultrastructure of tubular smooth endoplasmic reticulum aggregates in human metaphase II oocytes and clinical implications.人中期 II 卵母细胞管状光滑内质网聚集的超微结构及其临床意义。
Fertil Steril. 2011 Jul;96(1):143-149.e7. doi: 10.1016/j.fertnstert.2011.04.088. Epub 2011 May 31.
10
High proportion of immature oocytes in a cohort reduces fertilization, embryo development, pregnancy and live birth rates following ICSI.在接受 ICSI 治疗后，队列中未成熟卵母细胞比例高会降低受精率、胚胎发育率、妊娠率和活产率。
Reprod Biomed Online. 2019 Oct;39(4):580-587. doi: 10.1016/j.rbmo.2019.06.005. Epub 2019 Jun 18.
引用本文的文献
1
Smooth endoplasmic reticulum aggregates in oocytes: a comparison of progestin-primed and GnRH antagonist IVF protocols.卵母细胞中的滑面内质网聚集：孕激素预处理和促性腺激素释放激素拮抗剂体外受精方案的比较
J Ovarian Res. 2025 Aug 12;18(1):181. doi: 10.1186/s13048-025-01768-2.
2
Oocytes with aggregates of smooth endoplasmic reticulum may not affect reproductive outcomes in split IVF-ICSI insemination: a retrospective study.内质网聚集的卵母细胞在分裂期体外受精-卵胞浆内单精子注射授精中可能不影响生殖结局：一项回顾性研究
Front Endocrinol (Lausanne). 2025 Apr 29;16:1567066. doi: 10.3389/fendo.2025.1567066. eCollection 2025.
3
The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.《伊斯坦布尔共识更新：ESHRE/ALPHA关于卵母细胞和胚胎静态与动态形态学评估的修订共识》†，‡
Hum Reprod. 2025 Jun 1;40(6):989-1035. doi: 10.1093/humrep/deaf021.
4
Blastocysts originated from oocytes with smooth endoplasmic reticulum aggregates have a reduced euploidy rate: a retrospective cohort study.囊胚由具有光滑内质网聚集的卵母细胞产生，具有较低的整倍体率：一项回顾性队列研究。
Front Endocrinol (Lausanne). 2024 Sep 30;15:1425578. doi: 10.3389/fendo.2024.1425578. eCollection 2024.
5
The Relationship Between Smooth Endoplasmic Reticulum Clusters in Metaphase II Oocytes and Embryological and Birth Outcomes in Infertile Couples.中期II卵母细胞中滑面内质网簇与不育夫妇胚胎发育及出生结局的关系
Int J Gen Med. 2024 Jul 24;17:3269-3277. doi: 10.2147/IJGM.S469626. eCollection 2024.
6
Smooth endoplasmic reticulum aggregates in oocytes associated with increased risk of neonatal birth defects: A meta-analysis.卵母细胞中光滑内质网聚集与新生儿出生缺陷风险增加有关：一项荟萃分析。
Acta Obstet Gynecol Scand. 2024 Nov;103(11):2163-2170. doi: 10.1111/aogs.14910. Epub 2024 Jul 3.
7
SERa-Positive Oocyte Intracytoplasmic Injection and Its Outcome: A Case Report.血清学阳性卵母细胞胞浆内注射及其结果：一例报告
Cureus. 2024 Apr 23;16(4):e58836. doi: 10.7759/cureus.58836. eCollection 2024 Apr.
8
Live birth rate per transfer is not impacted by the proportion of smooth endoplasmatic reticulum aggregates oocytes.每次移植的活产率不受光滑内质网聚集体卵母细胞比例的影响。
Facts Views Vis Obgyn. 2023 Jun;15(2):137-144. doi: 10.52054/FVVO.15.2.070.
9
Does smooth endoplasmic reticulum aggregation in oocytes impact the chromosome aneuploidy of the subsequent embryos? A propensity score matching study.卵母细胞中光滑内质网聚集是否会影响随后胚胎的染色体非整倍体？一项倾向评分匹配研究。
J Ovarian Res. 2023 Mar 24;16(1):59. doi: 10.1186/s13048-023-01135-z.
10
Smooth endoplasmic reticulum cluster presence does not affect embryo ploidy.内质网簇的存在并不会影响胚胎的倍性。
Arch Gynecol Obstet. 2023 May;307(5):1607-1612. doi: 10.1007/s00404-023-06969-y. Epub 2023 Feb 17.
本文引用的文献
1
Can healthy babies originate from oocytes with smooth endoplasmic reticulum aggregates? A systematic mini-review.健康婴儿能否源自具有光滑内质网聚集的卵母细胞？系统小型综述。
Hum Reprod. 2014 Jul;29(7):1380-6. doi: 10.1093/humrep/deu101. Epub 2014 May 8.
2
Deliveries of normal healthy babies from embryos originating from oocytes showing the presence of smooth endoplasmic reticulum aggregates.正常健康婴儿的分娩来自于显示出光滑内质网聚集物的卵母细胞的胚胎。
Hum Reprod. 2013 Aug;28(8):2111-7. doi: 10.1093/humrep/det241. Epub 2013 May 21.
3
Ultrastructure of tubular smooth endoplasmic reticulum aggregates in human metaphase II oocytes and clinical implications.人中期 II 卵母细胞管状光滑内质网聚集的超微结构及其临床意义。
Fertil Steril. 2011 Jul;96(1):143-149.e7. doi: 10.1016/j.fertnstert.2011.04.088. Epub 2011 May 31.
4
The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting.《伊斯坦布尔胚胎评估共识工作坊：专家会议记录》。
Hum Reprod. 2011 Jun;26(6):1270-83. doi: 10.1093/humrep/der037. Epub 2011 Apr 18.
5
Mitochondrial function in the human oocyte and embryo and their role in developmental competence.人类卵母细胞和胚胎中的线粒体功能及其对发育能力的作用。
Mitochondrion. 2011 Sep;11(5):797-813. doi: 10.1016/j.mito.2010.09.012. Epub 2010 Oct 7.
6
Predictive value of oocyte morphology in human IVF: a systematic review of the literature.卵母细胞形态对人类 IVF 的预测价值：文献系统评价。
Hum Reprod Update. 2011 Jan-Feb;17(1):34-45. doi: 10.1093/humupd/dmq029. Epub 2010 Jul 16.
7
Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report.所有回收卵母细胞中均存在滑面内质网聚集，导致反复出现多种异常：病例报告。
Fertil Steril. 2009 Oct;92(4):1496.e1-1496.e3. doi: 10.1016/j.fertnstert.2009.06.048. Epub 2009 Jul 30.
8
Imprinting disorders and assisted reproductive technology.印记障碍与辅助生殖技术
Fertil Steril. 2009 Feb;91(2):305-15. doi: 10.1016/j.fertnstert.2009.01.002.
9
Prognosis of oocytes showing aggregation of smooth endoplasmic reticulum.显示滑面内质网聚集的卵母细胞的预后
Reprod Biomed Online. 2008 Jan;16(1):113-8. doi: 10.1016/s1472-6483(10)60563-9.
10
The relationship between pregnancy outcome and smooth endoplasmic reticulum clusters in MII human oocytes.MII期人类卵母细胞中妊娠结局与滑面内质网簇之间的关系。
Hum Reprod. 2004 Jul;19(7):1591-7. doi: 10.1093/humrep/deh258. Epub 2004 Jun 4.
Zotero 插件