Special Health Care Department, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China ; The Institute of Brain Science & Human Resource Management of Qingdao University, Qingdao 266003, Shandong Province, China.
The Institute of Brain Science & Human Resource Management of Qingdao University, Qingdao 266003, Shandong Province, China ; Department of Medical Imaging, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China.
Neural Regen Res. 2013 Dec 15;8(35):3344-52. doi: 10.3969/j.issn.1673-5374.2013.35.009.
Reward-based decision-making has been found to activate several brain areas, including the ventrolateral prefrontal lobe, orbitofrontal cortex, anterior cingulate cortex, ventral striatum, and mesolimbic dopaminergic system. In this study, we observed brain areas activated under three degrees of uncertainty in a reward-based decision-making task (certain, risky, and ambiguous). The tasks were presented using a brain function audiovisual stimulation system. We conducted brain scans of 15 healthy volunteers using a 3.0T magnetic resonance scanner. We used SPM8 to analyze the location and intensity of activation during the reward-based decision-making task, with respect to the three conditions. We found that the orbitofrontal cortex was activated in the certain reward condition, while the prefrontal cortex, precentral gyrus, occipital visual cortex, inferior parietal lobe, cerebellar posterior lobe, middle temporal gyrus, inferior temporal gyrus, limbic lobe, and midbrain were activated during the 'risk' condition. The prefrontal cortex, temporal pole, inferior temporal gyrus, occipital visual cortex, and cerebellar posterior lobe were activated during ambiguous decision-making. The ventrolateral prefrontal lobe, frontal pole of the prefrontal lobe, orbitofrontal cortex, precentral gyrus, inferior temporal gyrus, fusiform gyrus, supramarginal gyrus, inferior parietal lobule, and cerebellar posterior lobe exhibited greater activation in the 'risk' than in the 'certain' condition (P < 0.05). The frontal pole and dorsolateral region of the prefrontal lobe, as well as the cerebellar posterior lobe, showed significantly greater activation in the 'ambiguous' condition compared to the 'risk' condition (P < 0.05). The prefrontal lobe, occipital lobe, parietal lobe, temporal lobe, limbic lobe, midbrain, and posterior lobe of the cerebellum were activated during decision-making about uncertain rewards. Thus, we observed different levels and regions of activation for different types of reward processing during decision-making. Specifically, when the degree of reward uncertainty increased, the number of activated brain areas increased, including greater activation of brain areas associated with loss.
奖励决策已被发现激活了几个大脑区域，包括腹外侧前额叶皮层、眶额皮层、前扣带皮层、腹侧纹状体和中脑多巴胺能系统。在这项研究中，我们观察了在奖励决策任务（确定、风险和模糊）的三种不确定性程度下激活的大脑区域。任务使用脑功能视听刺激系统呈现。我们使用 3.0T 磁共振扫描仪对 15 名健康志愿者进行了脑扫描。我们使用 SPM8 分析了在奖励决策任务中三个条件下的大脑激活位置和强度。我们发现，在确定奖励条件下激活了眶额皮层，而在“风险”条件下激活了前额叶皮层、中央前回、枕叶视觉皮层、下顶叶、小脑后叶、中颞叶、下颞叶、边缘叶和中脑。在模糊决策时，前额叶皮层、颞极、下颞叶、枕叶视觉皮层和小脑后叶被激活。在风险条件下，腹外侧前额叶皮层、前额叶前极、眶额皮层、中央前回、下颞叶、梭状回、缘上回、下顶叶、小脑后叶表现出比确定条件更大的激活（P<0.05）。在模糊条件下，前额叶前极和额外侧区以及小脑后叶的激活显著大于风险条件（P<0.05）。在不确定奖励的决策过程中，前额叶、枕叶、顶叶、颞叶、边缘叶、中脑和小脑后叶被激活。因此，我们观察到不同类型的奖励处理在决策过程中具有不同的激活水平和区域。具体来说，当奖励不确定性程度增加时，激活的大脑区域数量增加，包括与损失相关的大脑区域的更大激活。
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