Department of Orthopedics, Second Hospital of Yueyang, Yueyang, Hunan Province, China.
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan, Hunan Province, China.
Neural Regen Res. 2014 Mar 15;9(6):602-9. doi: 10.4103/1673-5374.130101.
Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Schwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration (1.53 nmol/L) more significantly promoted Schwann cell migration than the highest FK506 concentration (100μmol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.
雷帕霉素与 FK506 相似，可促进体外神经再生。我们假设雷帕霉素和 FK506 促进周围神经再生的作用机制相似。本研究比较了不同浓度雷帕霉素和 FK506 对许旺细胞的影响，并探讨了雷帕霉素改善周围神经再生的作用及机制。结果表明，最低浓度雷帕霉素（1.53 nmol/L）比最高浓度 FK506（100μmol/L）更显著地促进许旺细胞迁移。雷帕霉素促进许旺细胞神经生长因子的分泌和上调生长相关蛋白 43 的表达，但对许旺细胞增殖无明显影响。因此，雷帕霉素在外周神经再生治疗中有潜在的应用价值。
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