Adv Exp Med Biol. 2014;810:192-207.
Human papillomaviruses (HPVs) infect squamous epithelia and can induce hyperproliferative lesions. More than 120 different HPV types have been characterized and classified into five different genera. While mucosal high-risk HPVs have a well-established causal role in anogenital carcinogenesis, the biology of cutaneous HPVs is less well understood. The clinical relevance of genus beta-PV infection has clearly been demonstrated in patients suffering from epidermodysplasia verruciformis (EV), a rare inherited disease associated with ahigh rate of skin cancer. In the normal population genus beta-PV are suspected to have an etiologic role in skin carcinogenesis as well but this is still controversially discussed. Their oncogenic potency has been investigated in mouse models and in vitro. In 2009, the International Agency for Research on Cancer (IARC) classified the genus beta HPV types 5 and 8 as "possible carcinogenic" biological agents (group 2B) in EV disease. This chapter will give an overview on the knowns and unknowns of infections with genus beta-PV and discuss their potential impact on skin carcinogenesis in the general population.
人乳头瘤病毒（HPV）感染鳞状上皮细胞，并可诱导过度增生性病变。已经鉴定出超过 120 种不同的 HPV 类型，并分为五个不同的属。虽然黏膜高危 HPV 已被明确证实与肛门生殖器癌的发生有关，但皮肤 HPV 的生物学特性仍知之甚少。β属 HPV 感染在患有疣状表皮发育不良（EV）的患者中具有明显的临床相关性，这是一种罕见的遗传性疾病，与皮肤癌的高发病率相关。在普通人群中，β属 HPV 也被怀疑在皮肤癌发生中具有病因作用，但这仍存在争议。已经在小鼠模型和体外实验中研究了它们的致癌潜力。2009 年，国际癌症研究机构（IARC）将β属 HPV 类型 5 和 8 列为 EV 疾病中的“可能致癌”生物制剂（第 2B 组）。本章将概述β属 HPV 感染的已知和未知情况，并讨论其对普通人群皮肤癌发生的潜在影响。
