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比较测量衍生(3DVH)和机器日志文件衍生的剂量重建方法用于患者几何结构中的容积调强放疗质量保证。

Comparing measurement-derived (3DVH) and machine log file-derived dose reconstruction methods for VMAT QA in patient geometries.

作者信息

Tyagi Neelam, Yang Kai, Yan Di

机构信息

Memorial Sloan-Kettering Cancer Center.

出版信息

J Appl Clin Med Phys. 2014 Jul 8;15(4):4645. doi: 10.1120/jacmp.v15i4.4645.

Abstract

The purpose of this study was to compare the measurement-derived (3DVH) dose reconstruction method with machine log file-derived dose reconstruction method in patient geometries for VMAT delivery. A total of ten patient plans were selected from a regular fractionation plan to complex SBRT plans. Treatment sites in the lung and abdomen were chosen to explore the effects of tissue heterogeneity on the respective dose reconstruction algorithms. Single- and multiple-arc VMAT plans were generated to achieve the desired target objectives. Delivered plan in the patient geometry was reconstructed by using ArcCHECK Planned Dose Perturbation (ACPDP) within 3DVH software, and by converting the machine log file to Pinnacle3 9.0 treatment plan format and recalculating dose with CVSP algorithm. In addition, delivered gantry angles between machine log file and 3DVH 4D measurement were also compared to evaluate the accuracy of the virtual inclinometer within the 3DVH. Measured ion chamber and 3DVH-derived isocenter dose agreed with planned dose within 0.4% ± 1.2% and -1.0% ± 1.6%, respectively. 3D gamma analysis showed greater than 98% between log files and 3DVH reconstructed dose. Machine log file reconstructed doses and TPS dose agreed to within 2% in PTV and OARs over the entire treatment. 3DVH reconstructed dose showed an average maximum dose difference of 3% ± 1.2% in PTV, and an average mean difference of -4.5% ± 10.5% in OAR doses. The average virtual inclinometer error (VIE) was -0.65° ± 1.6° for all patients, with a maximum error of -5.16° ± 4.54° for an SRS case. The time averaged VIE was within 1°-2°, and did not have a large impact on the overall accuracy of the estimated patient dose from ACPDP algorithm. In this study, we have compared two independent dose reconstruction methods for VMAT QA. Both methods are capable of taking into account the measurement and delivery parameter discrepancy, and display the delivered dose in CT patient geometry rather than the phantom geometry. The dose discrepancy can be evaluated in terms of DVH of the structures and provides a more intuitive understanding of the dosimetric impact of the delivery errors on the target and normal structure dose.

摘要

本研究的目的是比较测量衍生(3DVH)剂量重建方法与机器日志文件衍生剂量重建方法在容积调强弧形治疗(VMAT)患者几何结构中的应用。从常规分割计划到复杂的立体定向体部放疗(SBRT)计划中总共选择了10个患者计划。选择肺部和腹部的治疗部位来探究组织异质性对各自剂量重建算法的影响。生成单弧和多弧VMAT计划以实现预期的靶区目标。通过在3DVH软件中使用ArcCHECK计划剂量扰动(ACPDP),以及将机器日志文件转换为Pinnacle3 9.0治疗计划格式并使用CVSP算法重新计算剂量,来重建患者几何结构中的已交付计划。此外,还比较了机器日志文件和3DVH 4D测量之间的已交付机架角度,以评估3DVH内虚拟测角仪的准确性。测量的电离室和3DVH衍生的等中心剂量分别与计划剂量在0.4%±1.2%和-1.0%±1.6%范围内一致。三维伽马分析显示日志文件和3DVH重建剂量之间大于98%。在整个治疗过程中,机器日志文件重建剂量与治疗计划系统(TPS)剂量在计划靶体积(PTV)和危及器官(OAR)中相差在2%以内。3DVH重建剂量在PTV中显示平均最大剂量差异为3%±1.2%,在OAR剂量中平均平均差异为-4.5%±10.5%。所有患者的平均虚拟测角仪误差(VIE)为-0.65°±1.6°,立体定向放射外科(SRS)病例的最大误差为-5.16°±4.54°。时间平均VIE在1°-2°以内,对ACPDP算法估计的患者剂量的总体准确性没有很大影响。在本研究中,我们比较了两种独立的VMAT质量保证(QA)剂量重建方法。两种方法都能够考虑测量和交付参数差异,并在CT患者几何结构而非模体几何结构中显示已交付剂量。剂量差异可以根据结构的剂量体积直方图(DVH)进行评估,并能更直观地了解交付误差对靶区和正常结构剂量的剂量学影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c73/5875511/e7f5008a4ad2/ACM2-15-54-g001.jpg

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