Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway,
Eur J Nutr. 2014 Dec;53(8):1591-601. doi: 10.1007/s00394-014-0766-0. Epub 2014 Sep 11.
Greater body fatness has been associated with increased risk of gout in several studies; however, the strength of the association has differed between studies, and it is not clear whether the association differs by gender. We conducted a systematic review and meta-analysis of prospective studies to clarify the association between adiposity and risk of gout.
PubMed and Embase were searched up to August 30, 2013. Summary relative risks (RRs) were calculated using a random effects model.
Ten prospective studies of body mass index (BMI) and gout risk with 27,944 cases and 215,739 participants were included (median follow-up 10.5 years). The summary RR for a 5 unit increment was 1.55 [95% confidence interval (95% CI) 1.44-1.66, I(2) = 67%] for all studies combined. The heterogeneity was explained by one study, which appeared to be an outlier. The summary RR per 5 BMI units was 1.62 (95% CI 1.33-1.98, I(2) = 79%) for men and 1.49 (95% CI 1.32-1.68, I(2) = 30%) for women, p(heterogeneity) = 0.72. The relative risks were 1.78, 2.67, 3.62, and 4.64 for persons with BMI 25, 30, 35, and 40 compared with persons with a BMI of 20. BMI in young adulthood, waist-to-hip ratio, and weight gain from age 21-25 to midlife were also associated with increased risk, but few studies were included in these analyses.
Greater body mass index increases risk of gout. Further studies are needed on adiposity throughout the life course, waist-to-hip ratio, and weight changes in relation to gout as there were few studies that had published on these exposures.
多项研究表明，体脂含量增加与痛风风险增加有关；然而，不同研究之间的关联强度存在差异，且尚不清楚这种关联是否存在性别差异。我们进行了一项系统综述和荟萃分析，以明确肥胖与痛风风险之间的关系。
检索了 PubMed 和 Embase，检索截至 2013 年 8 月 30 日。使用随机效应模型计算汇总相对风险（RR）。
纳入了 10 项关于 BMI 和痛风风险的前瞻性研究，共涉及 27944 例病例和 215739 名参与者（中位随访时间为 10.5 年）。所有研究合并的汇总 RR 为 1.55（95%可信区间 1.44-1.66，I(2)=67%）。异质性由一项研究解释，该研究似乎为异常值。每增加 5 个 BMI 单位的汇总 RR 为男性 1.62（95%可信区间 1.33-1.98，I(2)=79%）和女性 1.49（95%可信区间 1.32-1.68，I(2)=30%），p(异质性)=0.72。与 BMI 为 20 的个体相比，BMI 为 25、30、35 和 40 的个体的相对风险分别为 1.78、2.67、3.62 和 4.64。年轻成年时的 BMI、腰围-臀围比以及从 21-25 岁到中年的体重增加也与风险增加相关，但这些分析中纳入的研究较少。
更大的 BMI 会增加痛风的风险。需要进一步研究整个生命过程中的肥胖、腰围-臀围比以及与痛风相关的体重变化，因为关于这些暴露的研究较少。
