全二维气相色谱/飞行时间质谱法分析硫熏对当归挥发成分的影响
Analysis of the influence of sulfur-fumigation on the volatile components of Angelicae sinensis Radix by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.
作者信息
Cao Gang, Cai Hao, Lou Yajing, Tu Sicong, Liu Xiao, Qin Kunming, Cai Baochang
机构信息
Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing ; Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou ; National First-Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing ; National First-Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
出版信息
Pharmacogn Mag. 2014 Jul;10(39):304-13. doi: 10.4103/0973-1296.137371.
BACKGROUND
Sulfur-fumigation of Angelicae sinensis Radix causes changes in the structure and composition of volatile components. These changes alter the curative effect and the quality of A. sinensis Radix.
MATERIALS AND METHODS
In this study, comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) was employed to investigate the influence of sulfur-fumigation on the volatile components, and to characterize and quantify the chemical composition of the volatile oil of A. sinensis Radix.
RESULTS
The present study has shown that sulfur-fumigated A. sinensis Radix samples had significant loss of the main active compounds and a more destructive fingerprint profile compared to non-fumigated samples.
CONCLUSION
From this study, it can be concluded that the combination of GC × GC and TOFMS has potential as a quality monitoring tool in herbal medicine and food processing industries.
背景
当归的硫熏处理会导致挥发性成分的结构和组成发生变化。这些变化会改变当归的疗效和质量。
材料与方法
在本研究中，采用全二维气相色谱-飞行时间质谱联用技术（GC×GC-TOFMS）来研究硫熏处理对挥发性成分的影响，并对当归挥发油的化学成分进行表征和定量分析。
结果
本研究表明，与未熏蒸的样品相比，硫熏处理的当归样品中主要活性成分有显著损失，且指纹图谱特征更具破坏性。
结论
从本研究可以得出结论，GC×GC和TOFMS联用在草药和食品加工业中作为质量监测工具具有潜力。
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