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纠正低维生素D水平可改善疲劳：低维生素D水平纠正对疲劳影响的研究（EViDiF研究）。

Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study).

作者信息

Roy Satyajeet, Sherman Anthony, Monari-Sparks Mary Joan, Schweiker Olga, Hunter Krystal

机构信息

Department of Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, New Jersey, USA.

Cooper Research Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, New Jersey, USA.

出版信息

N Am J Med Sci. 2014 Aug;6(8):396-402. doi: 10.4103/1947-2714.139291.

DOI:10.4103/1947-2714.139291
PMID:25210673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4158648/
Abstract

BACKGROUND

Fatigue is a common presenting complaint of patients in the primary care offices. Low levels of vitamin D have been associated with fatigue in cancer patients. Normalization of vitamin D level improves their fatigue. Whether low vitamin D plays a role in fatigue in medically stable patients is not known.

AIMS

This prospective non-randomized therapeutic study observed the prevalence of low vitamin D in fatigue and the effect of normalization of vitamin D on fatigue.

MATERIAL AND METHODS

One hundred and seventy four adult patients, who presented in our primary care office with fatigue and stable chronic medical conditions,completed fatigue assessment questionnaires. Patients with low vitamin D levels received ergocalciferol therapy for 5 weeks. Scores of pre- and post-treatment fatigue assessment questionnaires were compared.

RESULTS

Prevalence of low vitamin D was 77.2% in patients who presented with fatigue. After normalization of vitamin D levels fatigue symptom scores improved significantly (P < 0.001) in all five subscale categories of fatigue assessment questionnaires.

CONCLUSION

The prevalence of low vitamin D is high in patients who present with fatigue and stable chronic medical conditions, if any. Normalization of vitamin D levels with ergocalciferol therapy significantly improves the severity of their fatigue symptoms.

摘要

背景

疲劳是初级保健诊所患者常见的就诊主诉。维生素D水平低与癌症患者的疲劳有关。维生素D水平正常化可改善他们的疲劳症状。维生素D水平低是否在病情稳定的患者的疲劳中起作用尚不清楚。

目的

这项前瞻性非随机治疗研究观察了疲劳患者中维生素D水平低的患病率以及维生素D水平正常化对疲劳的影响。

材料与方法

174名因疲劳前来我们初级保健诊所就诊且患有稳定慢性疾病的成年患者完成了疲劳评估问卷。维生素D水平低的患者接受了5周的麦角钙化醇治疗。比较治疗前后疲劳评估问卷的得分。

结果

出现疲劳症状的患者中维生素D水平低的患病率为77.2%。维生素D水平正常化后，疲劳评估问卷所有五个子量表类别的疲劳症状得分均显著改善（P < 0.001）。

结论

出现疲劳症状且患有稳定慢性疾病（如有）的患者中维生素D水平低的患病率很高。麦角钙化醇治疗使维生素D水平正常化可显著改善其疲劳症状的严重程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fc/4158648/ad8e59f91694/NAJMS-6-396-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fc/4158648/eedb12c43032/NAJMS-6-396-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fc/4158648/ad8e59f91694/NAJMS-6-396-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fc/4158648/eedb12c43032/NAJMS-6-396-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fc/4158648/ad8e59f91694/NAJMS-6-396-g003.jpg

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