Askarinejad Amir, Bakhshandeh Hooman, Heidarali Mona, Adimi Sara, Ghaemmaghami Zahra, Haghjoo Majid
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
ARYA Atheroscler. 2024 Jan-Feb;20(1):31-40. doi: 10.48305/arya.2024.42018.2915.
Atrial fibrillation (AF) augments the risk of stroke by 4-5 times. Vitamin D is pivotal in numerous metabolic pathways. A handful of studies have explored the correlation between vitamin D deficiency (VDD) and AF outcomes. Hence, the authors sought to assess the relationship between VDD and AF outcomes.
From December 2021 to February 2023, 190 patients with AF were incorporated into the authors' study. Given the seasonal fluctuation of vitamin D levels, these levels were examined from the start of December until the end of March.
The final analysis comprised 190 patients (55.8% male) with an average age of 46.22±15.03. Vitamin D deficiency, insufficiency, and sufficiency were noted in 77 (40.5%), 46 (24.2%), and 67 (35.3%) patients, respectively. Fatigue and syncope were significantly more prevalent in the VDD group than in other groups. Three-vessel disease was more frequent in the VDD group (p-value=0.04). Mortality was more prevalent in patients with VDD (6.31%) compared to the VDI (2.10%) and VDS (0.05%) groups (p = 0.03). Successful cardioversion was significantly more prevalent in the VDS group (p = 0.03).
A sufficient level of vitamin D was linked with a better response to cardioversion. However, low vitamin D levels are correlated with higher mortality in AF patients.
心房颤动（AF）使中风风险增加4至5倍。维生素D在众多代谢途径中起关键作用。少数研究探讨了维生素D缺乏（VDD）与房颤结局之间的相关性。因此，作者试图评估VDD与房颤结局之间的关系。
从2021年12月至2023年2月，190例房颤患者纳入作者的研究。鉴于维生素D水平的季节性波动，从12月初至3月底对这些水平进行检测。
最终分析包括190例患者（男性占55.8%），平均年龄为46.22±15.03岁。维生素D缺乏、不足和充足的患者分别为77例（40.5%）、46例（24.2%）和67例（35.3%）。VDD组疲劳和晕厥的发生率明显高于其他组。VDD组三支血管病变更常见（p值=0.04）。VDD患者的死亡率（6.31%）高于维生素D不足（VDI）组（2.10%）和维生素D充足（VDS）组（0.05%）（p = 0.03）。VDS组成功复律的发生率明显更高（p = 0.03）。
充足的维生素D水平与更好的复律反应相关。然而，低维生素D水平与房颤患者较高的死亡率相关。
