Ellman Tanya M, Sexton Mary Elizabeth, Warshafsky Daniel, Sobieszczyk Magdalena E, Morrison Ellen A B
1 Division of Infectious Diseases, Columbia University , College of Physicians and Surgeons, New York, New York.
AIDS Patient Care STDS. 2014 Oct;28(10):530-6. doi: 10.1089/apc.2014.0152. Epub 2014 Sep 11.
Limited data are available regarding adults age ≥50 at initial HIV diagnosis. Improved understanding of this group is critical in designing interventions to facilitate earlier diagnosis and linkage to HIV care. We characterize individuals newly diagnosed with HIV, particularly those ≥50 years old, and examine the relationship between age and late diagnosis defined as concurrent HIV and AIDS diagnoses. This is a retrospective study of individuals newly diagnosed with HIV from 2006-2011 at an academic medical center in New York City. Multivariable logistic regression was performed to evaluate the effect of age, gender, race/ethnicity, risk factor, and prior medical visits on late diagnosis. Adults age ≥50 comprised 21.3% of all newly diagnosed individuals. Among these older adults, 70.0% were diagnosed as inpatients and 68.9% concurrent with AIDS, compared to 41.7% and 38.9% of younger adults, respectively. On adjusted analyses, age ≥50 (OR 3.13, 95% CI 1.63, 5.98) and injection drug use (OR 4.4, 95% CI 1.31, 14.75) were positively associated with late diagnosis, whereas female gender was negatively associated with late diagnosis (OR 0.52, 95% CI 0.28, 0.98). Our data suggest that HIV testing efforts targeting older adults are essential to address the unmet needs of this population, including implementation of HIV screening guidelines in primary care settings.
关于初次诊断为HIV时年龄≥50岁的成年人的数据有限。更好地了解这一群体对于设计促进早期诊断和与HIV治疗相衔接的干预措施至关重要。我们对新诊断为HIV的个体进行特征描述,尤其是那些年龄≥50岁的个体,并研究年龄与定义为HIV和艾滋病同时诊断的晚期诊断之间的关系。这是一项对2006年至2011年在纽约市一家学术医疗中心新诊断为HIV的个体进行的回顾性研究。进行多变量逻辑回归以评估年龄、性别、种族/族裔、危险因素和既往就诊情况对晚期诊断的影响。年龄≥50岁的成年人占所有新诊断个体的21.3%。在这些老年人中,70.0%是作为住院患者被诊断的,68.9%同时患有艾滋病,相比之下,年轻成年人的这两个比例分别为41.7%和38.9%。经校正分析,年龄≥50岁(比值比3.13,95%置信区间1.63,5.98)和注射吸毒(比值比4.4,95%置信区间1.31,14.75)与晚期诊断呈正相关,而女性与晚期诊断呈负相关(比值比0.52,95%置信区间0.28,0.98)。我们的数据表明,针对老年人的HIV检测工作对于满足这一人群未得到满足的需求至关重要,包括在初级保健机构实施HIV筛查指南。