补体的人膜辅因子蛋白（MCP）的结构基因定位于C3b/C4b受体基因3'端的100 kb范围内。
Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene.
作者信息
Bora N S, Lublin D M, Kumar B V, Hockett R D, Holers V M, Atkinson J P
机构信息
Howard Hughes Medical Institute Laboratories, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
J Exp Med. 1989 Feb 1;169(2):597-602. doi: 10.1084/jem.169.2.597.
Abstract
The structural gene for membrane cofactor protein (MCP), a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system, has been mapped to the same locus as the structural genes for CR1, CR2, DAF, and C4bp. The order of the genes within an approximately 800-kb DNA fragment on the long arm of chromosome 1 is MCP-CR1-CR2-DAF-C4bp. Further, the MCP gene maps to within 100 kb of 3' end of the CR1 gene.
摘要
膜辅因子蛋白（MCP）是补体系统中广泛分布的C3b/C4b结合调节糖蛋白，其结构基因已被定位到与CR1、CR2、衰变加速因子（DAF）和C4结合蛋白（C4bp）的结构基因相同的基因座上。1号染色体长臂上一个约800kb DNA片段内的基因顺序为MCP-CR1-CR2-DAF-C4bp。此外，MCP基因定位于CR1基因3'端100kb范围内。
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