人类补体激活调节基因簇的物理图谱，该基因簇连接补体基因CR1、CR2、DAF和C4BP。
A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP.
作者信息
Rey-Campos J, Rubinstein P, Rodriguez de Cordoba S
机构信息
Department of Immunogenetics, New York Blood Center 10021.
出版信息
J Exp Med. 1988 Feb 1;167(2):664-9. doi: 10.1084/jem.167.2.664.
Abstract
We report the organization of the human genes encoding the complement components C4-binding protein (C4BP), C3b/C4b receptor (CR1), decay accelerating factor (DAF), and C3dg receptor (CR2) within the regulator of complement activation (RCA) gene cluster. Using pulsed field gel electrophoresis analysis these genes have been physically linked and aligned as CR1-CR2-DAF-C4BP in an 800-kb DNA segment. The very tight linkage between the CR1 and the C4BP loci, contrasted with the relative long DNA distance between these genes, suggests the existence of mechanisms interfering with recombination within the RCA gene cluster.
摘要
我们报道了补体激活调节因子（RCA）基因簇中编码补体成分C4结合蛋白（C4BP）、C3b/C4b受体（CR1）、衰变加速因子（DAF）和C3dg受体（CR2）的人类基因的组织情况。通过脉冲场凝胶电泳分析，这些基因在一个800 kb的DNA片段中以CR1-CR2-DAF-C4BP的顺序物理连接并排列。CR1和C4BP基因座之间的紧密连锁，与这些基因之间相对较长的DNA距离形成对比，提示存在干扰RCA基因簇内重组的机制。
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