人类染色体1上RCA基因座中编码1型和2型补体受体、衰变加速因子及C4结合蛋白的基因组织
Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.
作者信息
Carroll M C, Alicot E M, Katzman P J, Klickstein L B, Smith J A, Fearon D T
机构信息
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
J Exp Med. 1988 Apr 1;167(4):1271-80. doi: 10.1084/jem.167.4.1271.
Abstract
The organization and physical linkage of four members of a major complement locus, the RCA locus, have been determined using the technique of pulsed field gradient gel electrophoresis in conjunction with Southern blotting. The genes encoding CR1, CR2, DAF, and C4bp were aligned in that order within a region of 750 kb. In addition, the 5' to 3' orientation of the CR1 gene (5' proximal to CR2) was determined using 5'- and 3'-specific DNA probes. The proximity of these genes may be related to structural and functional homologies of the protein products. Overall, a restriction map including 1,500 kb of DNA was prepared, and this map will be important for positioning of additional coding sequences within this region on the long arm of chromosome 1.
摘要
利用脉冲场梯度凝胶电泳技术结合Southern印迹法，已确定了主要补体基因座（RCA基因座）的四个成员的组织和物理连锁关系。编码CR1、CR2、DAF和C4bp的基因在750 kb的区域内按该顺序排列。此外，使用5'和3'特异性DNA探针确定了CR1基因的5'至3'方向（5'靠近CR2）。这些基因的邻近性可能与蛋白质产物的结构和功能同源性有关。总体而言，制备了包含1500 kb DNA的限制性图谱，该图谱对于在1号染色体长臂的该区域内定位其他编码序列将具有重要意义。
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Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.鉴定作为人类红细胞、多形核白细胞、B淋巴细胞和单核细胞C3b受体的膜糖蛋白。
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