Noguchi Memorial Institute for Medical Research, Accra, Ghana.
Navrongo Health Research Centre, Navrongo, Ghana.
Science. 2014 Sep 12;345(6202):1297-8. doi: 10.1126/science.1259423.
The African continent continues to bear the greatest burden of malaria and the greatest diversity of parasites, mosquito vectors, and human victims. The evolutionary plasticity of malaria parasites and their vectors is a major obstacle to eliminating the disease. Of current concern is the recently reported emergence of resistance to the front-line drug, artemisinin, in South-East Asia in Plasmodium falciparum, which calls for preemptive surveillance of the African parasite population for genetic markers of emerging drug resistance. Here we describe the Plasmodium Diversity Network Africa (PDNA), which has been established across 11 countries in sub-Saharan Africa to ensure that African scientists are enabled to work together and to play a key role in the global effort for tracking and responding to this public health threat.
非洲大陆继续承受着疟疾的最大负担和寄生虫、蚊子媒介和人类受害者的最大多样性。疟疾寄生虫及其媒介的进化可塑性是消除该疾病的主要障碍。目前令人关切的是，最近有报道称，在东南亚的恶性疟原虫中出现了对一线药物青蒿素的耐药性，这就要求对非洲寄生虫种群进行预先监测，以发现新出现的耐药性的遗传标记。在这里，我们描述了在撒哈拉以南非洲的 11 个国家建立的疟疾多样性网络非洲（PDNA），以确保非洲科学家能够共同努力，在追踪和应对这一公共卫生威胁的全球努力中发挥关键作用。
