Center for Disease Dynamics, Economics & Policy, Washington, DC, USA; Princeton Environmental Institute, Princeton, NJ, USA; Public Health Foundation of India, New Delhi, India.
Science. 2014 Sep 12;345(6202):1299-301. doi: 10.1126/science.1254163.
Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As with other such assets, keeping it available requires both conservation and innovation. Conservation encompasses making the best use of current antibiotic effectiveness by reducing demand through vaccination, infection control, diagnostics, public education, incentives for clinicians to prescribe fewer antibiotics, and restrictions on access to newer, last-resort antibiotics. Innovation includes improving the efficacy of current drugs and replenishing effectiveness by developing new drugs. In this paper, I assess the relative benefits and costs of these two approaches to maintaining our ability to treat infections.
抗生素的有效性是一种天然的社会资源，会因抗生素的使用而减少。与其他此类资产一样，要保持其可用性，既需要保护，也需要创新。保护包括通过疫苗接种、感染控制、诊断、公众教育、激励临床医生少开抗生素以及限制获取新型、最后手段的抗生素，来减少需求，从而最大限度地利用当前抗生素的有效性。创新包括提高现有药物的疗效，并通过开发新药来补充其有效性。在本文中，我评估了这两种方法在维持我们治疗感染的能力方面的相对益处和成本。
