Tapashetti Roopali P, Guvva Sowjanya, Patil Sudhir R, Sharma Sumit, Pushpalatha H M
Reader, Department of Periodontology, Al-Badar Rural Dental College and Hospital, Gulbarga, Karnataka, India.
Reader, Department of Periodontology, SVS Institute of Dental Sciences, Mahabubnagar, Andhra Pradesh, India.
J Int Oral Health. 2014 Jul;6(4):47-52.
C-reactive protein (CRP) - a prototypic marker of inflammation has been shown to be elevated in chronic periodontitis (CP) and also been shown to predict cardiovascular events. Increased carotid intima media thickness (CIMT) has been recently recognized as surrogate marker for atherosclerosis. In this context, we studied to correlate between CIMT and CRP in CP and to know whether CRP predicts the cardiovascular risk in CP.
The study consisted of 30 systemically healthy subjects aged over 40 years - 15 subjects with CP as cases and 15 subjects with no periodontitis as controls. All subjects were subjected to measurement of CRP levels and CIMT in addition to detailed periodontal evaluation. Quantitative determination of CRP was done by turbidimetric immunoassay. IMT of the common carotid arteries was estimated bilaterally using B-mode ultrasound at 6 sites. Positive CRP was defined as more than 10 mg/l.
Mean CRP levels were significantly higher in subjects with CP (19.58 ± 17.03), then in non CP (NCP) (5.54 ± 1.63, P < 0.004). Mean CIMT value was significantly higher in subjects with CP (1.09 ± 0.45) than in NCP (0.57 ± 0.06, P < 0.001) and all periodontal indices correlated well with CIMT. Further, there was significant correlation between CRP and increased CIMT in subjects with CP (r = 0.863, P < 0.001).
The present study indicates CRP as a possible underlying pathway in the association between periodontal disease and the observed CIMT. CRP can be used as a risk predictor for atherosclerosis in patients with CP.
C反应蛋白（CRP）——一种炎症的典型标志物，已被证明在慢性牙周炎（CP）中升高，并且还被证明可预测心血管事件。颈动脉内膜中层厚度（CIMT）增加最近被认为是动脉粥样硬化的替代标志物。在此背景下，我们研究了CP中CIMT与CRP之间的相关性，并了解CRP是否可预测CP中的心血管风险。
该研究包括30名40岁以上全身健康的受试者——15名患有CP的受试者作为病例，15名无牙周炎的受试者作为对照。除了详细的牙周评估外，所有受试者均接受了CRP水平和CIMT的测量。CRP的定量测定采用比浊免疫分析法。使用B型超声在双侧6个部位估计颈总动脉的IMT。CRP阳性定义为超过10mg/l。
CP患者的平均CRP水平（19.58±17.03）显著高于非CP（NCP）患者（5.54±1.6, P<0.004）。CP患者的平均CIMT值（1.09±0.45）显著高于NCP患者（0.57±0.06, P<0.001），并且所有牙周指数与CIMT均具有良好的相关性。此外，CP患者中CRP与CIMT增加之间存在显著相关性（r = 0.863, P<0.001）。
本研究表明CRP可能是牙周疾病与观察到CIMT之间关联的潜在途径。CRP可作为CP患者动脉粥样硬化的风险预测指标
