Eze Uchenna I, Eferakeya Adego E, Oparah Azuka C, Enato Ehijie F
Department of Clinical Pharmacy/Biopharmacy, Faculty of Pharmacy, Olabisi Onabanjo University Shagamu Campus, Shagamu ( Nigeria ).
Department of Pharmacology &Toxicology, Faculty of Pharmacy, University of Benin , Benin City ( Nigeria ).
Pharm Pract (Granada). 2007 Jul;5(3):135-9. doi: 10.4321/s1886-36552007000300007.
Managing medical complications in pregnancy is a challenge to clinicians.
This study profiled some disease and prescription patterns for pregnant women attending antenatal clinics (ANCs) in Nigeria. A risk classification of the medicines was also determined.
Medical case files of 1,200 pregnant women attending antenatal clinics of 3 health facilities in Benin City, Nigeria were investigated. Disease pattern was determined from their diagnoses. The prescription pattern was assessed using WHO indicators, and the United States Food and Drug Administration classification of medicines according to risk to the foetus.
A total of 1,897 prescriptions of the 1,200 pregnant women attendees during the period under review were evaluated. Results indicated that malaria 554 (38%) was the most prevalent disease, followed by upper respiratory tract infections (URTIs, 13%) and gastrointestinal disturbances (GIT, 12%). The average number of drugs prescribed per encounter was found to be 3.0, and 2,434 (43%) of medicines were prescribed by generic name. Minerals/ Vitamins 2,396 (42%) were the most frequently prescribed medicines, and antibiotics occurred in 502 (8.8%) of the total medicines. Of all medicines prescribed, 984 (17%) were included in the foetal risk category C and 286 (5%) in category D.
The study concluded that malaria fever occurred most frequently followed by URTIs and GIT disturbances among the pregnant women. Minerals, vitamins and to a less extent antimalarials topped the list of the prescribed medicines. The average number of medicines per encounter was much higher than WHO standards. The occurrence of contraindicated medicines was low.
孕期管理医疗并发症对临床医生来说是一项挑战。
本研究剖析了尼日利亚产前诊所(ANC)就诊孕妇的一些疾病及处方模式。还确定了药物的风险分类。
对尼日利亚贝宁城3家医疗机构产前诊所的1200名孕妇的医疗病例档案进行调查。根据诊断确定疾病模式。使用世界卫生组织指标评估处方模式,并根据药物对胎儿的风险采用美国食品药品监督管理局的药物分类。
在审查期间,对1200名孕妇就诊者的1897份处方进行了评估。结果表明,疟疾554例(38%)是最常见的疾病,其次是上呼吸道感染(URTI,13%)和胃肠道紊乱(GIT,12%)。每次就诊平均开的药数为3.0种,2434种(43%)药物以通用名开具。矿物质/维生素2396种(42%)是最常开具的药物,抗生素占总药物数量的502种(8.8%)。在所有开具的药物中,984种(17%)属于胎儿风险C类,286种(5%)属于D类。
该研究得出结论,孕妇中疟疾发热最为常见,其次是上呼吸道感染和胃肠道紊乱。矿物质、维生素以及较少程度的抗疟药在开具的药物中位居前列。每次就诊的平均药物数量远高于世界卫生组织标准。禁忌药物的出现率较低。