Beyens Marie-Noëlle, Guy Claire, Ratrema Martine, Ollagnier Michel
Centre Régional de Pharmacovigilance, Hôpital Bellevue, Saint-Etienne, France.
Therapie. 2003 Nov-Dec;58(6):505-11. doi: 10.2515/therapie:2003082.
The HIMAGE study, conducted in partnership with the principal Public Health Insurance Funds of the Loire region, analysed medicinal prescriptions during pregnancy on the basis of a representative sample of 911 pregnant women resident in this region of France. Altogether 93.5% received at least one prescription, with a mean of 10.9 different drugs per woman. The prescriptions were predominantly for drugs of the following Anatomical Therapeutic Chemical (ATC) classes: "alimentary tract and metabolism" (78%); "genito-urinary system and sex hormones" (62%); "nervous system" (62%); and "blood and blood-forming organs" (57%). Iron supplements, paracetamol, folic acid, magnesium, progesterone, oxaceprol, phloroglucinol, amoxicillin, domperidone and diosmine were the most frequently prescribed drugs. In total, 4.6% of the women were exposed to drugs involving a risk during pregnancy: principally nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed from the sixth month onwards. This study revealed a high frequency of prescription of drugs to pregnant women, largely motivated by non-rational and to some extent culture-specific considerations, and it also highlighted the prescription of drugs known to involve risk during pregnancy. These results provide a basis for advising clinicians on the rational and safe use of drugs during pregnancy.
HIMAGE研究与卢瓦尔地区主要的公共医疗保险基金合作开展，基于对居住在法国该地区的911名孕妇的代表性样本，分析了孕期的药物处方。总计93.5%的孕妇至少收到了一张处方，每位孕妇平均使用10.9种不同药物。这些处方主要针对以下解剖治疗学化学（ATC）分类的药物：“消化道及代谢”（78%）；“生殖泌尿系统及性激素”（62%）；“神经系统”（62%）；以及“血液及造血器官”（57%）。铁补充剂、对乙酰氨基酚、叶酸、镁、孕酮、奥沙普秦、间苯三酚、阿莫西林、多潘立酮和地奥司明是最常开具的药物。总体而言，4.6%的孕妇接触到了孕期有风险的药物：主要是从孕六个月起开具的非甾体抗炎药（NSAIDs）。这项研究揭示了孕妇用药处方的高频率，很大程度上是由不合理以及某种程度上特定文化因素驱动的，并且还突出了孕期已知有风险药物的处方情况。这些结果为指导临床医生在孕期合理安全用药提供了依据。
