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本文引用的文献

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Effect of β-sodium aescinate on hypoxia-inducible factor-1α expression in rat brain cortex after cardiopulmonary resuscitation.β-七叶皂苷钠对心肺复苏后大鼠大脑皮质缺氧诱导因子-1α表达的影响。
World J Emerg Med. 2013;4(1):63-8. doi: 10.5847/wjem.j.issn.1920-8642.2013.01.012.
2
The S100 protein family and its application in cardiac diseases.S100 蛋白家族及其在心脏疾病中的应用。
World J Emerg Med. 2010;1(3):165-8.
3
High S100B levels in cerebrospinal fluid and peripheral blood of patients with acute basal ganglial hemorrhage are associated with poor outcome.急性基底节区脑出血患者的脑脊液和外周血中 S100B 水平升高与不良预后相关。
World J Emerg Med. 2010;1(1):22-31.
4
[S-100B protein elevation in patients with the acute coronary syndrome after resuscitation is a predictor of adverse neurological prognosis].复苏后急性冠脉综合征患者S-100B蛋白升高是不良神经预后的预测指标
Vnitr Lek. 2012 Apr;58(4):266-72.
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Hemoglobin-based oxygen carriers for hemorrhagic shock.血红蛋白类氧载体治疗失血性休克。
Resuscitation. 2012 Mar;83(3):285-92. doi: 10.1016/j.resuscitation.2011.09.020. Epub 2011 Oct 5.
6
The significance of protein S-100B testing in cardiac arrest patients.蛋白 S-100B 检测在心搏骤停患者中的意义。
Clin Biochem. 2011 Jun;44(8-9):567-75. doi: 10.1016/j.clinbiochem.2011.03.133. Epub 2011 Mar 31.
7
S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-κB signaling.S100B 通过 RAGE 介导的 NF-κB 信号通路改变神经元的存活和树突延伸。
J Neurochem. 2011 Apr;117(2):321-32. doi: 10.1111/j.1471-4159.2011.07207.x. Epub 2011 Feb 25.
8
GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study.胶质纤维酸性蛋白和 S100B 是创伤性脑损伤的生物标志物：一项观察性队列研究。
Neurology. 2010 Nov 16;75(20):1786-93. doi: 10.1212/WNL.0b013e3181fd62d2.
9
S-100B is superior to NSE, BDNF and GFAP in predicting outcome of resuscitation from cardiac arrest with hypothermia treatment.S-100B 在预测低温治疗心脏骤停复苏结果方面优于 NSE、BDNF 和 GFAP。
Resuscitation. 2011 Jan;82(1):26-31. doi: 10.1016/j.resuscitation.2010.10.011. Epub 2010 Nov 10.
10
Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke.系统性炎症标志物与 S100B 浓度独立相关：急性缺血性脑卒中患者观察性研究的结果。
J Neuroinflammation. 2010 Oct 29;7:71. doi: 10.1186/1742-2094-7-71.

血清 S100B 蛋白在全脑缺血性损伤后升高。

S100B protein in serum is elevated after global cerebral ischemic injury.

机构信息

Department of Emergency Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing 210002, China.

出版信息

World J Emerg Med. 2013;4(3):165-8. doi: 10.5847/wjem.j.issn.1920-8642.2013.03.001.

DOI:10.5847/wjem.j.issn.1920-8642.2013.03.001
PMID:25215112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4129854/
Abstract

BACKGROUND

S100B protein in patients with cardiac arrest, hemorrhagic shock and other causes of global cerebral ischemic injury will be dramatically increased. Ischemic brain injury may elevate the level of serum S100B protein and the severity of brain damage.

METHODS

This article is a critical and descriptive review on S100B protein in serum after ischemic brain injury. We searched Pubmed database with key words or terms such as "S100B protein", "cardiac arrest", "hemorrhagic shock" and "ischemia reperfusion injury" appeared in the last five years.

RESULTS

S100B protein in patients with cardiac arrest, hemorrhagic shock and other causes of ischemic brain injury will be dramatically increased. Ischemic brain injury elevated the level of serum S100B protein, and the severity of brain damage.

CONCLUSION

The level of S100B protein in serum is elevated after ischemic brain injury, but its mechanism is unclear.

摘要

背景

心脏骤停、失血性休克和其他原因引起的全脑缺血性损伤患者的 S100B 蛋白会显著增加。脑缺血损伤可能会升高血清 S100B 蛋白的水平和脑损伤的严重程度。

方法

本文是一篇关于缺血性脑损伤后血清 S100B 蛋白的关键和描述性综述。我们在 Pubmed 数据库中使用了关键词或术语进行搜索，如“ S100B 蛋白”、“心脏骤停”、“失血性休克”和“缺血再灌注损伤”，这些关键词或术语在过去五年中出现过。

结果

心脏骤停、失血性休克和其他原因引起的缺血性脑损伤患者的 S100B 蛋白会显著增加。脑缺血损伤会升高血清 S100B 蛋白的水平，加重脑损伤的严重程度。

结论

缺血性脑损伤后血清 S100B 蛋白的水平升高，但机制尚不清楚。