Sollid Ludvig M, Pos Wouter, Wucherpfennig Kai W
Centre for Immune Regulation, Department of Immunology, University of Oslo and Oslo University Hospital - Rikshospitalet, 0372 Oslo, Norway.
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Curr Opin Immunol. 2014 Dec;31:24-30. doi: 10.1016/j.coi.2014.08.005. Epub 2014 Sep 15.
It will soon be 50 years since the first MHC associations with human disease were described. These seminal studies opened a flourishing area of research, yet much remains to be discovered. Genome-wide association studies of autoimmune diseases have demonstrated that the MHC region has effect sizes that supersede those for any non-MHC locus for most diseases. Thus, an understanding of how particular MHC alleles confer susceptibility will be essential for a comprehensive understanding of autoimmune disease pathogenesis. Here we review recent exciting findings in this important field.
自首次描述主要组织相容性复合体（MHC）与人类疾病的关联以来，很快就将迎来50年。这些开创性的研究开启了一个蓬勃发展的研究领域，但仍有许多有待发现。自身免疫性疾病的全基因组关联研究表明，对于大多数疾病而言，MHC区域的效应大小超过了任何非MHC基因座。因此，了解特定的MHC等位基因如何赋予易感性对于全面理解自身免疫性疾病发病机制至关重要。在此，我们综述了这一重要领域最近令人兴奋的发现。
