腺病毒E1A抑制细胞JE基因的转录。
Adenovirus E1A represses transcription of the cellular JE gene.
作者信息
Timmers H T, van Dam H, Pronk G J, Bos J L, Van der Eb A J
机构信息
Laboratory for Molecular Carcinogenesis, Sylvius Laboratories, University of Leiden, The Netherlands.
出版信息
J Virol. 1989 Mar;63(3):1470-3. doi: 10.1128/JVI.63.3.1470-1473.1989.
The expression of the growth factor-inducible JE gene was severely reduced in cells expressing region E1A of human adenoviruses. This reduction was not caused by a decreased stability of JE mRNA but by a reduced transcription rate as determined by run-on transcription experiments. Nevertheless, JE mRNA could still be induced by growth factors, suggesting that intracellular signaling is not blocked but rather that the basal level of JE transcription is repressed by E1A.
在表达人腺病毒E1A区的细胞中，生长因子诱导的JE基因的表达严重降低。这种降低不是由JE mRNA稳定性的降低引起的，而是由连续转录实验确定的转录速率降低所致。然而，JE mRNA仍可被生长因子诱导，这表明细胞内信号传导未被阻断，而是JE转录的基础水平被E1A抑制。
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