Moraga Fernando A, Jiménez Daniel, Richalet Jean Paul, Vargas Manuel, Osorio Jorge
Laboratorio de Fisiología, Hipoxia y Función Vascular, Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Católica del Norte, Coquimbo, Chile.
Medicina de Altura Ltda., Santiago, Chile.
Respir Physiol Neurobiol. 2014 Nov 1;203:109-15. doi: 10.1016/j.resp.2014.09.001. Epub 2014 Sep 9.
Our objective was to determine the nocturnal ventilatory pattern and characterize the effect of oxygen enrichment on nocturnal ventilatory pattern and sleep quality in miners exposed to intermittent hypobaric hypoxia at 4200m. A total of 16 acclimatized miners were studied. Nocturnal ventilatory pattern (plethysmographic inductance), arterial oxygen saturation and heart rate (pulse oximetry) were performed in 9/16 subjects. Sleep quality at high altitude was assessed by self-questionnaires in 16/16 subjects. All measurements were performed during at least 7h of sleep. Subjects were studied while sleeping at high altitude without (control, C) and with oxygen supplementation (FiO2=0.25, treated, T). Periodic breathing (%) C: 25±18 vs T: 6.6±5.6 (p<0.05), apneas index (no./h) C: 34.9±24.1 vs T: 8.5±6.8 (p<0.05); and sleep quality C: 17.8±3.4 vs T: 12.1±2.2 (p<0.0001) were evaluated. In conclusion, periodic breathing with apneas was present in miners exposed to high altitude for 1 to 4 years and was reduced by treatment with supplementary oxygen.
我们的目的是确定在海拔4200米处暴露于间歇性低压缺氧环境下的矿工的夜间通气模式，并描述富氧对其夜间通气模式和睡眠质量的影响。共研究了16名已适应环境的矿工。对其中9/16的受试者进行了夜间通气模式（体积描记电感法）、动脉血氧饱和度和心率（脉搏血氧饱和度测定法）的检测。对16/16的受试者通过自我问卷调查评估了高海拔地区的睡眠质量。所有测量均在至少7小时的睡眠期间进行。受试者在高海拔地区睡眠时分别在不吸氧（对照组，C）和吸氧（吸入氧分数=0.25，治疗组，T）的情况下接受研究。评估了周期性呼吸（%）：C组为25±18，T组为6.6±5.6（p<0.05）；呼吸暂停指数（次/小时）：C组为34.9±24.1，T组为8.5±6.8（p<0.05）；以及睡眠质量：C组为17.8±3.4，T组为12.1±2.2（p<0.0001）。总之，暴露于高海拔环境1至4年的矿工存在伴有呼吸暂停的周期性呼吸，补充氧气治疗可使其减少。
