抗磷脂酰丝氨酸和抗磷脂酰乙醇胺抗体的发生率与系统性红斑狼疮临床表现之间的关联。

Associations between the incidence of antiphosphatidylserine and antiphosphatidylethanolamine antibodies and clinical manifestations of systemic lupus erythematosus.

作者信息

Butkiewicz Filip, Kaszuba Michał, Brzeziński Michał, Iżbicki Jan, Kubiś Marek, Lopiński Hubert, Borowiak Michał, Szelepajło Michał, Fischer Katarzyna, Fliciński Jacek

出版信息

Pol Arch Med Wewn. 2014;124(11):573-8. doi: 10.20452/pamw.2489. Epub 2014 Sep 15.

DOI:10.20452/pamw.2489

Abstract

INTRODUCTION

Antiphosphatidylethanolamine antibodies (aPE) and antiphosphatidylserine antibodies (aPS) belong to a group of antiphospholipid antibodies (aPL) that occur in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE).

OBJECTIVES

The aim of this study was to examine associations between the elevated serum concentration of aPE/aPS, the clinical manifestations of SLE, and the presence of other autoantibodies.

PATIENTS AND METHODS

The study group included 71 patients with SLE. The control group comprised 36 healthy volunteers. In both groups, serum aPS and aPE concentrations were measured with enzyme‑linked immunosorbent assays. Clinical data, including clinical manifestations and the laboratory markers of SLE, were obtained from medical records.

RESULTS

The study revealed a higher prevalence of aPE in patients with SLE than in controls (54.93% vs. 5.56%). aPS were observed in the study group less frequently compared with aPE (12.68% vs. 54.93%) and were absent in controls. Anticardiolipin antibodies and APS were found to be associated with the presence of aPS. Thrombocytopenia, Raynaud phenomenon, and myocardial infarction were observed more frequently among aPS‑positive patients. The presence of aPE was also associated with the occurrence of mucosal ulcers in the mouth cavity. A positive correlation between aPS and erythrocyte sedimentation rate (ESR) was also observed. The serum concentration of aPE inversely correlated with red blood cell count and positively with ESR.

CONCLUSIONS

The presence of aPS in patients with SLE is associated with thrombocytopenia, Raynaud phenomenon, and cardiac complications.

摘要

引言

抗磷脂酰乙醇胺抗体（aPE）和抗磷脂酰丝氨酸抗体（aPS）属于抗磷脂抗体（aPL）组，见于抗磷脂综合征（APS）和系统性红斑狼疮（SLE）患者。

目的

本研究旨在探讨血清aPE/aPS浓度升高与SLE临床表现及其他自身抗体存在之间的关联。

患者与方法

研究组包括71例SLE患者。对照组由36名健康志愿者组成。两组均采用酶联免疫吸附测定法检测血清aPS和aPE浓度。临床资料，包括SLE的临床表现和实验室指标，均从病历中获取。

结果

研究发现SLE患者中aPE的患病率高于对照组（54.93%对5.56%）。与aPE相比，研究组中aPS的观察频率较低（12.68%对54.93%），且对照组中未检测到。抗心磷脂抗体和APS与aPS的存在相关。在aPS阳性患者中，血小板减少症、雷诺现象和心肌梗死更为常见。aPE的存在也与口腔黏膜溃疡的发生有关。还观察到aPS与红细胞沉降率（ESR）呈正相关。aPE的血清浓度与红细胞计数呈负相关，与ESR呈正相关。

结论

SLE患者中aPS的存在与血小板减少症、雷诺现象和心脏并发症相关。