Levine Arie
Pediatric Gastroenterology Unit, Wolfson Medical Center, Tel Aviv University, Holon, Israel.
Nestle Nutr Inst Workshop Ser. 2014;79:131-40. doi: 10.1159/000360719. Epub 2014 Sep 5.
Crohn's disease (CD) is a complex inherited disorder of unknown pathogenesis. Recent evidence suggests that CD may involve genetic or environmental factors that impair the normal innate immune system's ability to contain bacteria to the lumen. Multiple dietary components may impact on the resident flora, diminish or damage the mucous layer, increase intestinal permeability or increase the ability of pathobionts to adhere to epithelial cells or translocate across the epithelial barrier. This chapter reviews the possible effects of different dietary components present in the Western diet to affect bacterial clearance mechanisms, and offers a hypothetical model for an acquired bacterial clearance defect in CD.
克罗恩病（CD）是一种发病机制不明的复杂遗传性疾病。最近的证据表明，CD可能涉及遗传或环境因素，这些因素会损害正常的固有免疫系统将细菌限制在肠腔内的能力。多种饮食成分可能会影响肠道菌群，减少或破坏黏液层，增加肠道通透性，或增强病原菌黏附上皮细胞或穿过上皮屏障的能力。本章综述了西方饮食中不同饮食成分对细菌清除机制可能产生的影响，并提出了一个关于CD中获得性细菌清除缺陷的假说模型。
