Pediatric Gastroenterology Unit, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Holon, Israel.
Inflamm Bowel Dis. 2013 May;19(6):1322-9. doi: 10.1097/MIB.0b013e3182802acc.
Crohn's disease is a complex inherited disorder of unknown pathogenesis with environmental, genetic, and microbial factors involved in the development of the disease. A remarkable feature of this disease, especially, but not limited to childhood, is the effective response to exclusive enteral nutrition therapy and the observed benefit from exclusion of normal diet (principle of exclusivity). We reviewed the possible mechanisms of action of enteral nutrition for induction of remission and provided a hypothetical model (herein termed bacterial penetration cycle) that integrates dietary components, bacteria, susceptibility genes, and the innate immune response in the pathogenesis of Crohn's disease.
克罗恩病是一种复杂的遗传性疾病，其发病机制尚不清楚，涉及环境、遗传和微生物因素。这种疾病的一个显著特征是，特别是在儿童中，但不仅限于儿童，对专门的肠内营养治疗有显著反应，并且观察到排除正常饮食（排他性原则）有益。我们回顾了肠内营养诱导缓解的可能作用机制，并提出了一个假设模型（本文称为细菌渗透循环），该模型将饮食成分、细菌、易感性基因和先天免疫反应整合到克罗恩病的发病机制中。
