Mercadier J J, Zongazo M A, Wisnewsky C, Butler-Brown G, Gros D, Carayon A, Schwartz K
INSERM U 127, Hôpital Lariboisière, Paris, France.
Biochem Biophys Res Commun. 1989 Mar 15;159(2):777-82. doi: 10.1016/0006-291x(89)90062-4.
We have investigated the level of expression of the atrial natriuretic factor (ANF) gene in the human heart during ontogenic development by determining the concentrations of ANF messenger ribonucleic acid (ANF mRNA), of immunoreactive ANF (IR ANF) and of receptor reactive ANF (RR ANF), in myocardial samples of the various heart chambers. We found the level was high and almost identical in the left and right ventricles in utero. It gradually decreased during ontogenic development to reach the low adult levels, with a more rapid decrease in the right than in the left ventricle after birth. In the atria, ANF gene expression was high as early as the 13th week of gestation, was higher in the right than in the left atrium, and appeared little affected by ontogenic development.
我们通过测定不同心腔心肌样本中心房钠尿肽信使核糖核酸（ANF mRNA）、免疫反应性心房钠尿肽（IR ANF）和受体反应性心房钠尿肽（RR ANF）的浓度，研究了个体发育过程中人类心脏中心房钠尿肽（ANF）基因的表达水平。我们发现，在子宫内时，左、右心室中的该水平较高且几乎相同。在个体发育过程中，它逐渐下降至成人的低水平，出生后右心室的下降速度比左心室更快。在心房中，早在妊娠第13周时ANF基因表达就很高，右心房中的表达高于左心房，并且似乎几乎不受个体发育的影响。
