Floege Jürgen
Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Pauwelsstr. 30, 52057, Aachen, Germany,
J Nephrol. 2015 Jun;28(3):269-77. doi: 10.1007/s40620-014-0140-6. Epub 2014 Sep 17.
Magnesium fulfils important roles in multiple physiological processes. Accordingly, a tight regulation of magnesium homeostasis is essential. Dysregulated magnesium serum levels, in particular hypomagnesaemia, are common in patients with chronic kidney disease (CKD) and have been associated with poor clinical outcomes. In cell culture studies as well as in clinical situations magnesium levels were associated with vascular calcification, cardiovascular disease and altered bone-mineral metabolism. Magnesium has also been linked to diseases such as metabolic syndrome, diabetes, hypertension, fatigue and depression, all of which are common in CKD. The present review summarizes and discusses the latest clinical data on the impact of magnesium and possible effects of higher levels on the health status of patients with CKD, including an outlook on the use of magnesium-based phosphate-binding agents in this context.
镁在多种生理过程中发挥着重要作用。因此，严格调节镁稳态至关重要。慢性肾脏病（CKD）患者中，镁血清水平失调，尤其是低镁血症很常见，且与不良临床结局相关。在细胞培养研究以及临床情况下，镁水平与血管钙化、心血管疾病和骨矿物质代谢改变有关。镁还与代谢综合征、糖尿病、高血压、疲劳和抑郁等疾病有关，所有这些在CKD中都很常见。本综述总结并讨论了关于镁的影响以及较高水平对CKD患者健康状况可能产生的影响的最新临床数据，包括在此背景下使用镁基磷结合剂的前景。
