Rodríguez-Moran Martha, Guerrero-Romero Fernando
Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas # 100, Col. Los Angeles, ZC 34067 Durango, Mexico.
Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas # 100, Col. Los Angeles, ZC 34067 Durango, Mexico.
Eur J Intern Med. 2014 Feb;25(2):128-31. doi: 10.1016/j.ejim.2013.08.706. Epub 2013 Sep 11.
Given the potential implications in the policies focused on the prevention of hypertension, we evaluate the relationship between low serum magnesium levels and prehypertension in otherwise healthy subjects.
A cross-sectional study that enrolled 175 healthy men and non-pregnant women, 20 to 65 years of age was carried out. Type 2 diabetes, impaired fasting glucose, hypertension, chronic diarrhea, cancer, impaired renal function, as well as the intake of magnesium supplements in the previous six months, were the exclusion criteria. Hypomagnesemia was defined by serum magnesium concentration of <0.7 mmol/L and prehypertension by Systolic (S) and Diastolic (D) blood pressure (BP) of 120 to 139 and 80 to 89 mmHg. A multivariate logistic conditional forward analysis, adjusted by sex, age, alcohol consumption waist circumference, body mass index, fasting glucose and triglyceride levels was conducted to evaluate the association between hypomagnesemia and prehypertension.
Prehypertension was identified in 68 (13.2%) subjects who were compared with 107 (20.8%) control individuals without prehypertension. Individuals with prehypertension showed lower magnesium (0.73±0.20 vs. 0.77±0.21, p<0.001) and higher triglyceride levels (2.8±3.5 vs. 1.8±1.2, p=0.04) as compared with non-prehypertensive individuals. There were no other significant differences between the groups. The adjusted multivariate logistic conditional forward analysis showed a significant association between hypomagnesemia and prehypertension (OR 1.98; 95% CI 1.11-4.20, p=0.04).
Our finding suggests that low serum magnesium levels could play an important role in the pathophysiology of prehypertension in otherwise healthy subjects.
鉴于关注高血压预防的政策可能受到的影响，我们评估了健康人群中低血清镁水平与高血压前期之间的关系。
开展了一项横断面研究，纳入了175名年龄在20至65岁之间的健康男性和非妊娠女性。排除标准包括2型糖尿病、空腹血糖受损、高血压、慢性腹泻、癌症、肾功能受损以及过去六个月内服用镁补充剂的情况。低镁血症定义为血清镁浓度<0.7 mmol/L，高血压前期定义为收缩压（S）和舒张压（D）分别为120至139 mmHg和80至89 mmHg。进行了多因素逻辑条件向前分析，并根据性别、年龄、饮酒量、腰围、体重指数、空腹血糖和甘油三酯水平进行了调整，以评估低镁血症与高血压前期之间的关联。
在68名（13.2%）受试者中发现了高血压前期，将其与107名（20.8%）无高血压前期的对照个体进行比较。与非高血压前期个体相比，高血压前期个体的镁水平较低（0.73±0.20 vs. 0.77±0.21，p<0.001），甘油三酯水平较高（2.8±3.5 vs. 1.8±1.2，p=0.04）。两组之间没有其他显著差异。经调整的多因素逻辑条件向前分析显示，低镁血症与高血压前期之间存在显著关联（比值比1.98；95%置信区间1.11-4.20，p=0.04）。
我们的研究结果表明，在其他方面健康的人群中，低血清镁水平可能在高血压前期的病理生理过程中起重要作用。
