• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

功能化碳纳米管-聚合物杂化物的制备及毒理学评估

Preparation and toxicological assessment of functionalized carbon nanotube-polymer hybrids.

作者信息

Koromilas Nikos D, Lainioti Georgia Ch, Gialeli Chrisostomi, Barbouri Despoina, Kouravelou Katerina B, Karamanos Nikos K, Voyiatzis George A, Kallitsis Joannis K

机构信息

Department of Chemistry, University of Patras, Patras, Greece; Foundation for Research and Technology-Hellas (FORTH) / Institute of Chemical Engineering Sciences (ICE-HT), Rio-Patras, Greece.

Nanothinx S.A., Rio-Patras, Greece.

出版信息

PLoS One. 2014 Sep 17;9(9):e107029. doi: 10.1371/journal.pone.0107029. eCollection 2014.

DOI:10.1371/journal.pone.0107029
PMID:25229474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4167694/
Abstract

Novel Carbon Nanotube-Polymer Hybrids were synthesized as potential materials for the development of membranes for water treatment applications in the field of Membrane Bioreactors (MBRs). Due to the toxicological concerns regarding the use of nanomaterials in water treatment as well as the rising demand for safe drinking water to protect public health, we studied the functionalization of MWCNTs and Thin-MWCNTs as to control their properties and increase their ability of embedment into porous anisotropic polymeric membranes. Following the growth of the hydrophilic monomer on the surface of the properly functionalized CNTs, that act as initiator for the controlled radical polymerization (ATRP) of sodium styrene sulfonate (SSNa), the antimicrobial quaternized phosphonium and ammonium salts were attached on CNTs-g-PSSNa through non-covalent bonding. In another approach the covalent attachment of quaternized ammonium polymeric moieties of acrylic acid-vinyl benzyl chloride copolymers with N,N-dimethylhexadecylamine (P(AA12-co-VBCHAM)) on functionalized CNTs has also been attempted. Finally, the toxicological assessment in terms of cell viability and cell morphological changes revealed that surface characteristics play a major role in the biological response of functionalized CNTs.

摘要

新型碳纳米管-聚合物杂化材料被合成出来，作为膜生物反应器（MBR）领域中用于开发水处理应用膜的潜在材料。由于在水处理中使用纳米材料存在毒理学问题，以及对安全饮用水以保护公众健康的需求不断增加，我们研究了多壁碳纳米管（MWCNTs）和薄壁多壁碳纳米管（Thin-MWCNTs）的功能化，以控制它们的性能并提高它们嵌入多孔各向异性聚合物膜的能力。在适当功能化的碳纳米管表面生长亲水性单体后，该单体作为苯乙烯磺酸钠（SSNa）可控自由基聚合（ATRP）的引发剂，抗菌季铵化鏻盐和铵盐通过非共价键连接到碳纳米管-g-PSSNa上。在另一种方法中，还尝试了将丙烯酸-乙烯基苄基氯共聚物与N，N-二甲基十六烷基胺（P(AA12-co-VBCHAM)）的季铵化铵聚合物部分共价连接到功能化的碳纳米管上。最后，关于细胞活力和细胞形态变化的毒理学评估表明，表面特性在功能化碳纳米管的生物反应中起主要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/1abb5fb92cff/pone.0107029.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/dc9c6997e225/pone.0107029.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/73fd47b447bf/pone.0107029.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/72e96702f3de/pone.0107029.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/1553a03546e8/pone.0107029.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/e13d1e29a7b2/pone.0107029.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/ed98ae5d2dd0/pone.0107029.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/6675108a4708/pone.0107029.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/0c1469d82628/pone.0107029.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/c4712d173e20/pone.0107029.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/660de3cf8736/pone.0107029.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/3927dcb84680/pone.0107029.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/d7a230312d37/pone.0107029.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/1abb5fb92cff/pone.0107029.g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/dc9c6997e225/pone.0107029.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/73fd47b447bf/pone.0107029.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/72e96702f3de/pone.0107029.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/1553a03546e8/pone.0107029.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/e13d1e29a7b2/pone.0107029.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/ed98ae5d2dd0/pone.0107029.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/6675108a4708/pone.0107029.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/0c1469d82628/pone.0107029.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/c4712d173e20/pone.0107029.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/660de3cf8736/pone.0107029.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/3927dcb84680/pone.0107029.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/d7a230312d37/pone.0107029.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a401/4167694/1abb5fb92cff/pone.0107029.g013.jpg

相似文献

1
Preparation and toxicological assessment of functionalized carbon nanotube-polymer hybrids.功能化碳纳米管-聚合物杂化物的制备及毒理学评估
PLoS One. 2014 Sep 17;9(9):e107029. doi: 10.1371/journal.pone.0107029. eCollection 2014.
2
Evaluation of Antimicrobial Efficiency of New Polymers Comprised by Covalently Attached and/or Electrostatically Bound Bacteriostatic Species, Based on Quaternary Ammonium Compounds.基于季铵化合物的、由共价连接和/或静电结合的抑菌物质组成的新型聚合物的抗菌效率评估。
Molecules. 2015 Dec 1;20(12):21313-27. doi: 10.3390/molecules201219768.
3
Water-dispersible carbon nanotubes for aqueous surface-initiated atom transfer radical polymerization.用于水相表面引发原子转移自由基聚合的水分散性碳纳米管
J Nanosci Nanotechnol. 2008 Nov;8(11):5858-63.
4
Facile fabrication of glycosylated and PEGylated carbon nanotubes through the combination of mussel inspired chemistry and surface-initiated ATRP.通过贻贝启发的化学和表面引发的原子转移自由基聚合相结合，实现糖基化和聚乙二醇化碳纳米管的简易制备。
Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110157. doi: 10.1016/j.msec.2019.110157. Epub 2019 Sep 3.
5
Glycopolymer decorated multiwalled carbon nanotubes for dual targeted breast cancer therapy.糖基聚合物修饰的多壁碳纳米管用于双重靶向乳腺癌治疗。
J Mater Chem B. 2020 Apr 21;8(15):3123-3137. doi: 10.1039/c9tb02711d. Epub 2020 Mar 25.
6
Advances in the biomedical application of polymer-functionalized carbon nanotubes.聚合物功能化碳纳米管在生物医学中的应用进展。
Biomater Sci. 2015 May;3(5):695-711. doi: 10.1039/c4bm00421c. Epub 2015 Feb 16.
7
The combination of Diels-Alder reaction and redox polymerization for preparation of functionalized CNTs for intracellular controlled drug delivery.通过 Diels-Alder 反应和氧化还原聚合制备功能化 CNTs 用于细胞内控制药物释放。
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110442. doi: 10.1016/j.msec.2019.110442. Epub 2019 Nov 18.
8
Investigation of the adsorption of polymer chains on amine-functionalized double-walled carbon nanotubes.聚合物链在胺功能化双壁碳纳米管上的吸附研究。
J Mol Model. 2015 Dec;21(12):312. doi: 10.1007/s00894-015-2858-z. Epub 2015 Nov 19.
9
Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors.质粒DNA与功能化碳纳米管的结合与凝聚：迈向基于纳米管的基因传递载体的构建
J Am Chem Soc. 2005 Mar 30;127(12):4388-96. doi: 10.1021/ja0441561.
10
Non-covalent functionalization of single-walled carbon nanotubes with modified polyethyleneimines for efficient gene delivery.用改性聚乙烯亚胺对单壁碳纳米管进行非共价功能化以实现高效基因传递。
Int J Pharm. 2013 Sep 15;454(1):204-15. doi: 10.1016/j.ijpharm.2013.06.057. Epub 2013 Jul 12.

引用本文的文献

1
Raman Spectroscopy Unfolds the Fate and Transformation of SWCNTs after Abrasive Wear of Epoxy Floor Coatings.拉曼光谱揭示了环氧地坪涂料磨蚀磨损后单壁碳纳米管的命运与转变。
Nanomaterials (Basel). 2024 Jan 3;14(1):120. doi: 10.3390/nano14010120.
2
Functionalized carbon nanotubes: synthesis, properties and applications in water purification, drug delivery, and material and biomedical sciences.功能化碳纳米管：合成、性质及其在水净化、药物递送以及材料与生物医学科学中的应用
Nanoscale Adv. 2021 Aug 9;3(20):5722-5744. doi: 10.1039/d1na00293g. eCollection 2021 Oct 12.
3
Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment.

本文引用的文献

1
Understanding the toxicity of carbon nanotubes in the environment is crucial to the control of nanomaterials in producing and processing and the assessment of health risk for human: a review.了解环境中碳纳米管的毒性对于控制生产和加工过程中的纳米材料以及评估人类健康风险至关重要：综述。
Environ Toxicol Pharmacol. 2013 Sep;36(2):451-462. doi: 10.1016/j.etap.2013.05.007. Epub 2013 May 24.
2
Cationic antimicrobial polymers and their assemblies.阳离子抗菌聚合物及其组装体。
Int J Mol Sci. 2013 May 10;14(5):9906-46. doi: 10.3390/ijms14059906.
3
Carbon nanotubes: present and future commercial applications.
功能化碳纳米结构与耐药性：癌症治疗中的有前景方案。
Molecules. 2020 Apr 30;25(9):2102. doi: 10.3390/molecules25092102.
4
Enhanced Water Vapor Transmission through Porous Membranes Based on Melt Blending of Polystyrene Sulfonate with Polyethylene Copolymers and Their CNT Nanocomposites.基于聚苯乙烯磺酸盐与聚乙烯共聚物及其碳纳米管纳米复合材料的熔融共混制备的多孔膜的水蒸气透过率增强
Polymers (Basel). 2016 May 12;8(5):190. doi: 10.3390/polym8050190.
5
Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses.用于药物靶向的表面改性多功能及刺激响应纳米颗粒：现状与应用
Int J Mol Sci. 2016 Aug 31;17(9):1440. doi: 10.3390/ijms17091440.
6
Impact of single-walled carbon nanotubes on the embryo: a brief review.单壁碳纳米管对胚胎的影响：简要综述。
Int J Nanomedicine. 2016 Jan 21;11:349-55. doi: 10.2147/IJN.S96361. eCollection 2016.
7
Evaluation of Antimicrobial Efficiency of New Polymers Comprised by Covalently Attached and/or Electrostatically Bound Bacteriostatic Species, Based on Quaternary Ammonium Compounds.基于季铵化合物的、由共价连接和/或静电结合的抑菌物质组成的新型聚合物的抗菌效率评估。
Molecules. 2015 Dec 1;20(12):21313-27. doi: 10.3390/molecules201219768.
碳纳米管：当前和未来的商业应用。
Science. 2013 Feb 1;339(6119):535-9. doi: 10.1126/science.1222453.
4
Inhibitory effects of multiwall carbon nanotubes with high iron impurity on viability and neuronal differentiation in cultured PC12 cells.高铁杂质多壁碳纳米管对培养 PC12 细胞活力和神经元分化的抑制作用。
Toxicology. 2013 Nov 8;313(1):49-58. doi: 10.1016/j.tox.2012.11.011. Epub 2012 Dec 3.
5
Functionalized carbon nanotubes: biomedical applications.功能化碳纳米管：生物医学应用。
Int J Nanomedicine. 2012;7:5361-74. doi: 10.2147/IJN.S35832. Epub 2012 Oct 9.
6
Inhaled chemotherapy in lung cancer: safety concerns of nanocomplexes delivered.肺癌的吸入式化疗：纳米复合物给药的安全性问题
Ther Deliv. 2012 Sep;3(9):1021-3. doi: 10.4155/tde.12.77.
7
Understanding the toxicity of carbon nanotubes.了解碳纳米管的毒性。
Acc Chem Res. 2013 Mar 19;46(3):702-13. doi: 10.1021/ar300028m. Epub 2012 Sep 21.
8
Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab.panitumumab 抑制细胞外基质大分子的表达和表皮生长因子反应性结肠癌细胞的功能特性。
Invest New Drugs. 2013 Jun;31(3):516-24. doi: 10.1007/s10637-012-9875-x. Epub 2012 Sep 6.
9
Dimethyl sulfoxide promotes the multiple functions of the tumor suppressor HLJ1 through activator protein-1 activation in NSCLC cells.二甲基亚砜通过激活蛋白-1 激活促进非小细胞肺癌细胞中肿瘤抑制因子 HLJ1 的多种功能。
PLoS One. 2012;7(4):e33772. doi: 10.1371/journal.pone.0033772. Epub 2012 Apr 17.
10
Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo.暴露于电离辐射会导致人肺成纤维细胞提前衰老，进而增强恶性肺上皮细胞在体外和体内的生长。
Int J Oncol. 2011 Oct;39(4):989-99. doi: 10.3892/ijo.2011.1132. Epub 2011 Jul 19.