Hou Chuanwei, He Qian, Yang Chunhao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China.
Org Lett. 2014 Oct 3;16(19):5040-3. doi: 10.1021/ol502381e. Epub 2014 Sep 17.
A novel and direct synthesis of various 2-aminobenzo[b]thiophenes has been developed. The reactions were catalyzed by a combination of Pd(dppf)Cl2 and dppf using odorless and cheap Na2S2O3 as the sulfur source. This strategy allowed us to synthesize important 2-aminobenzo[b]thiophene scaffold more efficiently and conveniently.
已开发出一种新颖且直接的合成各种2-氨基苯并[b]噻吩的方法。反应由Pd(dppf)Cl2和dppf组合催化，使用无味且廉价的Na2S2O3作为硫源。该策略使我们能够更高效、便捷地合成重要的2-氨基苯并[b]噻吩骨架。
