Gu Zheng-Yang, Cao Jia-Jia, Wang Shun-Yi, Ji Shun-Jun
Key Laboratory of Organic Synthesis of Jiangsu Province , College of Chemistry , Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology , Soochow University , Suzhou 215123 , China . Email:
Chem Sci. 2016 Jul 1;7(7):4067-4072. doi: 10.1039/c6sc00240d. Epub 2016 Mar 11.
An efficient and practical synthesis of benzothiazine by KS initiated sulfur insertion reaction with enaminones electron catalysis is developed. This protocol provides a new, environment-friendly and simple strategy to construct benzothiazine derivatives formation of two C-S bonds under transition metal-free, additive-free and oxidant-free conditions. KS not only provides the sulfur insertion source, but also ignites the reaction through the formation of a trisulfur radical anion and electrons in DMF.
通过KS引发的硫插入反应与烯胺酮进行电子催化，开发了一种高效实用的苯并噻嗪合成方法。该方案提供了一种新的、环境友好且简单的策略，用于在无过渡金属、无添加剂和无氧化剂的条件下构建苯并噻嗪衍生物并形成两个C-S键。KS不仅提供硫插入源，还通过在DMF中形成三硫自由基阴离子和电子引发反应。
