Shen Ting, Qiu Meihui, Li Chao, Zhang Jie, Wu Zhiguo, Wang Biao, Jiang Kaida, Peng Daihui
aDivision of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine bHuashan Hospital, Fudan University, Shanghai, China.
Neuroreport. 2014 Nov 12;25(16):1302-7. doi: 10.1097/WNR.0000000000000263.
Abnormal brain function is presumed to be a pathophysiological aspect of major depressive disorder (MDD). However, the underlying patterns of spontaneous neural activity have been poorly characterized and replicated to date. In this study, we applied a novel approach of fractional amplitude of low-frequency fluctuation (fALFF) to investigate the alteration of spontaneous neural activity in MDD. Sixteen first-episode, unmedicated patients with MDD and 16 healthy controls were recruited and subjected to resting-state fMRI scans to measure the fALFF across the whole brain. Compared with healthy controls, MDD patients exhibited decreased fALFF in the right angular gyrus, left middle temporal gyrus, left superior temporal gyrus, right putamen, right precuneus, and the right superior temporal gyrus. Differences in fALFF between MDD patients and controls indicated that altered spontaneous neural activity was distributed across a number of specific brain regions among MDD patients. These atypical functional regions may help explain some of the neural processes underlying the clinical symptoms accompanying MDD.
异常脑功能被认为是重度抑郁症（MDD）的病理生理方面。然而，迄今为止，自发神经活动的潜在模式尚未得到充分表征和重复验证。在本研究中，我们应用了一种低频振幅分数（fALFF）的新方法来研究MDD患者自发神经活动的改变。招募了16名首次发作、未接受药物治疗的MDD患者和16名健康对照者，并对其进行静息态功能磁共振成像扫描，以测量全脑的fALFF。与健康对照者相比，MDD患者在右侧角回、左侧颞中回、左侧颞上回、右侧壳核、右侧楔前叶和右侧颞上回的fALFF降低。MDD患者与对照者之间fALFF的差异表明，MDD患者中自发神经活动的改变分布在多个特定脑区。这些非典型功能区可能有助于解释伴随MDD的临床症状背后的一些神经过程。
