Yulug Burak, Yalcinkaya Ali, Safa Shair Shah, Sayman Dila, Cankaya Seyda, Karakus Ayse, Sayman Ceyhun, Uygur Abdullah Burak, Bircan Emir Izzet, Ucak Aydogan Dogukan, Velioglu Halil Aziz, Hanoglu Lutfu, Mardinoglu Adil
Department of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, 07400, Antalya, Türkiye.
Functional Imaging and Cognitive-Affective Neuroscience Lab (fINCAN), Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, 34815, Istanbul, Türkiye.
Transl Psychiatry. 2025 Sep 1;15(1):335. doi: 10.1038/s41398-025-03518-w.
Depressive cognitive impairment is seen in a significant number of patients with depression. However, it remains challenging to differentiate between patients with amnestic (those with subjective cognitive impairment complaints) and non-amnestic major depressive disorder, highlighting the urgent need for additional objective tools to help classify these patients more accurately. We analyzed cognitive state, alterations in regional entropy and functional connectivity measures of the brain between patients with major depression and healthy controls. The depressed cohort was categorized as either "amnestic" or "non-amnestic," depending on self-reported experiences of forgetfulness. The superior temporal region and insula exhibited altered entropy and connectivity measures in individuals with depression and subjective cognitive impairment, which was correlated with impaired executive functions, a pattern not being evident in the control group. Our findings support the notion that insular and superior temporal entropic alterations are linked to subjective cognitive changes in the pathology of depression. These regions also hold potential as biomarkers for determining the underlying objective cognitive deficits in subjective cognitive complaints in patients with major depressive disorder (MDD). This underscores the need for improved diagnostic approaches and the implementation of practical dynamic neuroimaging modalities capable of addressing the current challenges in diagnosing subjective cognitive impairment in MDD, offering promise for the future management of patients with depression.
大量抑郁症患者存在抑郁性认知障碍。然而，区分遗忘型（有主观认知障碍主诉的患者）和非遗忘型重度抑郁症患者仍然具有挑战性，这凸显了迫切需要更多客观工具来更准确地对这些患者进行分类。我们分析了重度抑郁症患者和健康对照者之间的认知状态、大脑区域熵和功能连接测量的变化。根据自我报告的遗忘经历，抑郁症队列被分为“遗忘型”或“非遗忘型”。颞上区和脑岛在患有抑郁症和主观认知障碍的个体中表现出熵和连接测量的变化，这与执行功能受损相关，而在对照组中这种模式并不明显。我们的研究结果支持这样一种观点，即脑岛和颞上区的熵改变与抑郁症病理中的主观认知变化有关。这些区域也有可能作为生物标志物，用于确定重度抑郁症（MDD）患者主观认知主诉中潜在的客观认知缺陷。这强调了需要改进诊断方法，并实施能够应对当前MDD主观认知障碍诊断挑战的实用动态神经成像模式，为未来抑郁症患者的管理带来希望。
