肾移植受者注射OKT3单克隆抗体后血清中肿瘤坏死因子、白细胞介素-2和γ-干扰素的释放

Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients.

作者信息

Abramowicz D, Schandene L, Goldman M, Crusiaux A, Vereerstraeten P, De Pauw L, Wybran J, Kinnaert P, Dupont E, Toussaint C

机构信息

Départment Médico-Chirurgical de Néphrologie, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Belgium.

出版信息

Transplantation. 1989 Apr;47(4):606-8. doi: 10.1097/00007890-198904000-00008.

DOI:10.1097/00007890-198904000-00008

PMID:2523100

Abstract

High levels of tumor necrosis factor-alpha, interleukin-2, and gamma-interferon appeared in the circulation of kidney transplant recipients after the first injection of the monoclonal antibody OKT3. This initial injection was systematically followed by fever. The three cytokines were released in all patients (n = 9), with peak serum levels of tumor necrosis factor occurring 1 hr after OKT3 injection and those of interleukin-2 and gamma-interferon after 2 hr. Cytokines were not released after the second and third OKT3 injections, when CD3+ cells had disappeared from blood. These findings suggest that circulating cytokines are released by T cells after activation by OKT3. These cytokines are probably involved in the systematic reactions observed after injection of OKT3.

摘要

首次注射单克隆抗体OKT3后，肾移植受者循环系统中出现高水平的肿瘤坏死因子-α、白细胞介素-2和γ-干扰素。首次注射后系统性地出现发热。所有9例患者均释放了这三种细胞因子，肿瘤坏死因子血清峰值水平在注射OKT3后1小时出现，白细胞介素-2和γ-干扰素的血清峰值水平在注射后2小时出现。在第二次和第三次注射OKT3后，当血液中CD3+细胞消失时，细胞因子未释放。这些发现表明，循环细胞因子是由OKT3激活后的T细胞释放的。这些细胞因子可能与注射OKT3后观察到的全身反应有关。