转移性癌症干细胞：从概念到治疗
Metastatic cancer stem cells: from the concept to therapeutics.
作者信息
Liao Wen-Ting, Ye Ya-Ping, Deng Yong-Jian, Bian Xiu-Wu, Ding Yan-Qing
机构信息
Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou 510515, China.
Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University Chongqing 400038, China.
出版信息
Am J Stem Cells. 2014 Sep 5;3(2):46-62. eCollection 2014.
Metastatic cancer stem cells (MCSCs) refer to a subpopulation of cancer cells with both stem cell properties and invasion capabilities that contribute to cancer metastasis. MCSCs have capability of self-renewal, potentials of multiple differentiation and development and/or reconstruction of cancer tissues. As compared with stationary cancer stem cells, MCSCs are capable of invasion to normal tissues such as vasculatures, resistance to chemo- and/or radio-therapies, escape from immune surveillance, survival in circulation and formation of metastasis. MCSCs are derived from invasive cancer stem cells (iCSCs) due to the plasticity of cancer stem cells, which is one of the characteristics of cancer cell heterogeneity. Both stages of iCSCs and MSCSs are the potential therapeutic targets for cancer metastasis in the future strategies of personalized cancer therapy.
转移性癌症干细胞（MCSCs）是指具有干细胞特性和侵袭能力的癌细胞亚群，它们促进癌症转移。MCSCs具有自我更新能力、多向分化潜能以及癌症组织发育和/或重建的潜能。与静止的癌症干细胞相比，MCSCs能够侵袭血管等正常组织，对化学疗法和/或放射疗法具有抗性，逃避免疫监视，在循环中存活并形成转移灶。由于癌症干细胞的可塑性，MCSCs来源于侵袭性癌症干细胞（iCSCs），这是癌细胞异质性的特征之一。iCSCs和MSCSs阶段都是未来个性化癌症治疗策略中癌症转移的潜在治疗靶点。
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