Keast D, Nguyen T, Newsholme E A
Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
FEBS Lett. 1989 Apr 10;247(1):132-4. doi: 10.1016/0014-5793(89)81255-4.
The activities of key glycolytic enzymes are, in general, similar at the three different ages of the animals used in this work (very young, adult and old). Glutaminase is present in skin of both mice and rats, but the activity was much lower in adult animals compared to the very young or the old. It is suggested that this activity is important for the provision of nitrogen for the de novo synthesis of purine and pyrimidine nucleotides during the growth of skin in the young animal and for DNA repair in the old animals; it might be important in the adult skin in response to wound healing.
在本研究中所使用的三种不同年龄段的动物（幼龄、成年和老龄）中，关键糖酵解酶的活性总体上是相似的。谷氨酰胺酶存在于小鼠和大鼠的皮肤中，但与幼龄或老龄动物相比，成年动物中的活性要低得多。据推测，这种活性对于幼龄动物皮肤生长过程中嘌呤和嘧啶核苷酸从头合成提供氮以及老龄动物的DNA修复很重要；在成年皮肤应对伤口愈合时可能也很重要。
